The role of prophylactic cefazolin in the prevention of infection after various types of abdominal wall hernia repair with mesh

Mehrabi Bahar, M. and Jabbari Nooghabi, A. and Jabbari Nooghabi, M. and Jangjoo, A. (2015) The role of prophylactic cefazolin in the prevention of infection after various types of abdominal wall hernia repair with mesh. Asian Journal of Surgery, 38 (3). pp. 139-144.

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Summary Objective There are controversies about the benefits of prophylactic antibiotics in the prevention of postoperative surgical site infection (SSI) in mesh herniorrhaphy for a long time. This study aimed to evaluate the effectiveness and efficacy of systemic prophylactic cefazolin in prevention of wound infection in various types of hernia repair with mesh materials. Methods This is a prospective randomized control study. We evaluated wound infection rates in 395 patients with various kinds of hernia who underwent elective mesh repair using polypropylene mesh from 2007 to 2011. A total of 237 (60.0) patients received prophylactic cefazolin (study group) and the remaining 158 (40.0) patients did not receive any prophylactic antibiotics (control group). Patients were followed for infection at the following periods after the operation by an independent surgeon: 10 days, 30 days, 12 months, and then annually for at least 2 years. Results Eight (2.03) patients had infection in the site of surgery 2 (1.27%) in the control group and 6 (2.53%) in the study group. The distribution of infection was not significantly different between the two groups (p = 0.364). The superficial infections were managed by drainage and irrigation. One patient from the study group developed deep SSI and was readmitted and subsequently received antibiotic therapy, drainage, and debridement. Conclusion Preoperative administration of single-dose cefazolin for prosthetic hernia repairs did not markedly decrease the risk of wound infection. Our results do not support the use of cefazolin as a prophylactic antibiotic for various kinds of abdominal wall hernia repair with mesh. Copyright © 2015, Asian Surgical Association.

Item Type: Article
Additional Information: Cited By :4 Export Date: 16 February 2020 CODEN: AJSUE Correspondence Address: Jangjoo, A.; Surgical Oncology Research Center, Imam Reza Hospital, Mashhad University of Medical SciencesIran
Uncontrolled Keywords: antibiotic prophylaxis hernia herniorrhaphy infection surgical mesh ventral antiinfective agent cefazolin adult aged controlled study devices female follow up Hernia, Abdominal human male middle aged procedures prospective study randomized controlled trial Staphylococcal Infections Surgical Wound Infection treatment outcome Anti-Bacterial Agents Follow-Up Studies Humans Prospective Studies
Subjects: WO Surgery
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 17 May 2020 10:19
Last Modified: 17 May 2020 10:19

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