Phaeohyphomycosis due to Exophiala xenobiotica as a cause of fungal arthritis in an HIV-infected patient

Morio, F. and Berre, J. Y. L. and Dea, G. H. and Najafzadeh, M. J. and De Hoog, S. and Benard, L. and Michau, C. (2012) Phaeohyphomycosis due to Exophiala xenobiotica as a cause of fungal arthritis in an HIV-infected patient. Medical Mycology, 50 (5). pp. 513-517.

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Black yeasts including Exophiala species are increasingly recognized as agents of human disease. In recent years, progress in molecular phylogeny and taxonomy of the genus Exophiala has led to the description of numerous novel species. The 'classical' but highly variable species Exophiala jeanselmei was split into a number of morphological siblings, which, however, were phylogenetically and clinically remote from each other. E. jeanselmei was restricted to an uncommon species causing subcutaneous infections. Hence only limited information is available on the segregants, among which is E. xenobiotica. We describe a case of an HIV-patient presenting with fungal arthritis and subcutaneous nodules caused by the latter species, which was identified by means of phenotypic and molecular methods. © 2012 ISHAM.

Item Type: Article
Additional Information: Cited By :12 Export Date: 16 February 2020 CODEN: MEMYF Correspondence Address: Morio, F.; Laboratoire de Parasitologie-Mycologie, CHU de Nantes, Hôtel Dieu, 9 Quai Moncousu, F-44093 Nantes Cedex 1, France; email:
Uncontrolled Keywords: Arthritis Black yeast Exophiala xenobiotica Immune reconstitution inflammatory syndrome Molecular identification Phaeohyphomycosis amphotericin B caspofungin fungal DNA itraconazole posaconazole voriconazole adult article blood culture case report CD4 lymphocyte count exophiala jeanselmei fungus fungus culture fungus identification highly active antiretroviral therapy histopathology human Human immunodeficiency virus 1 infection Human immunodeficiency virus infected patient human tissue hygroma joint biopsy male minimum inhibitory concentration nucleotide sequence phenotype physical examination subcutaneous mycosis subcutaneous nodule virus load AIDS-Related Opportunistic Infections Arthritis, Infectious DNA, Fungal Exophiala HIV Infections Humans Middle Aged Molecular Sequence Data Mycological Typing Techniques Sequence Analysis, DNA Subcutaneous Tissue
Subjects: WC Communicable Diseases
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 15 May 2020 22:00
Last Modified: 15 May 2020 22:00

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