Clinical applications of saffron (Crocus sativus) and its constituents: A review

Moshiri, M. and Vahabzadeh, M. and Hosseinzadeh, H. (2015) Clinical applications of saffron (Crocus sativus) and its constituents: A review. Drug Research, 65 (6). pp. 287-295.

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Abstract

Commonly known as saffron, Crocus sativus L and its active components have shown several useful pharmacological effects such as anticonvulsant, antidepressant, anti-inflammatory, antitumor, radical scavenger effects, learning and memory improving effects, etc. There has been an increasing body of data on saffron use in medical databases within the last 20 years. In the current review, the strengths and weaknesses of some of the clinical trials about different pharmacological effects of saffron will be discussed C. sativus extract has been studied in 8 anti-depressant clinical trials in comparison to placebo or some antidepressant drugs, in which saffron showed effectiveness as an antidepressant drug. Clinical trials on anti-Alzheimer effect of saffron demonstrated that it was more effective than the placebo, and as effective as donepezil. 2 clinical trials on antipruritic and complexion promoter in skin care effects of saffron both confirmed that saffron was more efficient than the placebo. In another clinical trial, it was proved that in addition to the weight loss treatment, saffron could reduce snacking frequency. Clinical trials conducted on women with premenstrual syndrome showed that saffron could reduce suffering symptoms more than the placebo and similar to standard treatments. Furthermore, additional clinical trials on effects of saffron on erection dysfunction, allergies, cardiovascular and immune system as well as its safety, toxicity and human pharmacokinetics are reviewed herein. © Georg Thieme Verlag KG Stuttgart New York.

Item Type: Article
Additional Information: Cited By :45 Export Date: 16 February 2020 CODEN: DRSGA Correspondence Address: Hosseinzadeh, H.; Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, P.O. Box 91775, Iran
Uncontrolled Keywords: clinical crocin Crocus sativus saffron safranal Crocus sativus extract donepezil antidepressant agent antipruritic agent plant extract allergy Alzheimer disease antidepressant activity Article cardiovascular system clinical trial (topic) comparative study constipation controlled clinical trial (topic) decreased appetite depression diarrhea dizziness drowsiness drug effect drug efficacy drug safety dysmenorrhea erectile dysfunction fatigue headache human hypomania immune system increased appetite infertility insomnia mood disorder nausea nonhuman paresthesia premenopause premenstrual syndrome randomized controlled trial (topic) restlessness sexual dysfunction side effect skin care skin tingling stomach pain tremor urine retention vomiting weight reduction xerostomia animal chemistry Crocus drug effects female Animals Antidepressive Agents Antipruritics Clinical Trials as Topic Humans Plant Extracts Weight Loss
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 03 May 2020 07:58
Last Modified: 03 May 2020 07:58
URI: http://eprints.mums.ac.ir/id/eprint/18993

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