Beneficial effects of teucrium polium and metformin on diabetes-induced memory impairments and brain tissue oxidative damage in rats

Mousavi, S. M. and Niazmand, S. and Hosseini, M. and Hassanzadeh, Z. and Sadeghnia, H. R. and Vafaee, F. and Keshavarzi, Z. (2015) Beneficial effects of teucrium polium and metformin on diabetes-induced memory impairments and brain tissue oxidative damage in rats. International Journal of Alzheimer's Disease, 2015.

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Abstract

Objective. The effects of hydroalcoholic extract of Teucrium polium and metformin on diabetes-induced memory impairment and brain tissues oxidative damage were investigated. Methods. The rats were divided into: (1) Control, (2) Diabetic, (3) Diabetic-Extract 100 (Dia-Ext 100), (4) Diabetic-Extract 200 (Dia-Ext 200), (5) Diabetic-Extract 400 (Dia-Ext 400), and (6) Diabetic-Metformin (Dia-Met). Groups 3-6 were treated by 100, 200, and 400 mg/kg of the extract or metformin, respectively, for 6 weeks (orally). Results. In passive avoidance test, the latency to enter the dark compartment in Diabetic group was lower than that of Control group (P < 0.01). In Dia-Ext 100, Dia-Ext 200, and Dia-Ext 400 and Metformin groups, the latencies were higher than those of Diabetic group (P < 0.01). Lipid peroxides levels (reported as malondialdehyde, MDA, concentration) in the brain of Diabetic group were higher than Control (P < 0.001). Treatment by all doses of the extract and metformin decreased the MDA concentration (P < 0.01). Conclusions. The results of present study showed that metformin and the hydroalcoholic extract of Teucrium polium prevent diabetes-induced memory deficits in rats. Protection against brain tissues oxidative damage might have a role in the beneficial effects of the extract and metformin. © 2015 S. Mojtaba Mousavi et al.

Item Type: Article
Additional Information: Cited By :27 Export Date: 16 February 2020 Correspondence Address: Hosseini, M.; Neurocognitive Research Center, School of Medicine, Mashhad University of Medical SciencesIran
Uncontrolled Keywords: glucose lipid peroxide malonaldehyde metformin Teucrium polium extract animal experiment animal model animal tissue Article brain damage brain tissue comparative study controlled study electric shock germander glucose blood level hippocampus latent period lipid blood level long term care male memory disorder neuroprotection nonhuman oxidative stress passive avoidance test priority journal rat streptozotocin-induced diabetes mellitus
Subjects: WL Nervous system
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 03 May 2020 06:04
Last Modified: 03 May 2020 06:04
URI: http://eprints.mums.ac.ir/id/eprint/18995

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