Etiological diagnosis of community-acquired pneumonia in adult patients: A prospective hospital-based study in Mashhad, Iran

Naderi, H. and Sheybani, F. and Sarvghad, M. and Meshkat, Z. and Nooghabi, M. J. (2015) Etiological diagnosis of community-acquired pneumonia in adult patients: A prospective hospital-based study in Mashhad, Iran. Jundishapur Journal of Microbiology, 8 (8).

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Abstract

Background: Pneumonia is the third most common cause of death in the world, and mortality is highest for patients who require hospitalization. Objectives: This prospective observational study is an etiological survey of community-acquired pneumonia (CAP) over a 12-month period in the Iranian city of Mashhad. To our knowledge, this is one of the first prospective hospital-based studies to comprehensively evaluate the epidemiological, demographical, clinical, and prognostic factors of patients with CAP in Iran. Patients and Methods: We studied all adult patients (aged ≥ 16 years) with CAP admitted to Imam Reza Hospital, Mashhad, Iran, between February 2013 and January 2014. The etiological diagnosis of CAP was made through conventional culturing and staining of respiratory secretions (i.e. sputum and pleural fluid), standard BACTEC™ Plus Aerobic/F bottles for blood cultures, and the immunochromatographic assays BinaxNOW® Streptococcus pneumoniae antigen and BinaxNOW® Legionella pneumophila antigen for the detection of S. pneumoniae antigen and L. pneumophila serogroup 1 antigen, respectively. Results: Among 120 patients with CAP, the most common etiology was S. pneumoniae (24.4), followed by Mycobacterium tuberculosis (17.5), S. aureus (6.7), polymicrobial agents including anaerobes (4.2), complicated hydatid cyst (2.5), Influenza A virus (4.2; including 2 cases of mixed Influenza A-bacterial infection), and Klebsiella pneumoniae, Brucella melitensis, Mucor, and varicella, each in 0.8 of the patients. The diagnosis of pneumonia remained unknown in 49 (40) patients. Conclusions: Tuberculosis was an important cause of CAP in our region. Hence, it should be considered in all patients admitted with a CAP diagnosis. © 2015, Ahvaz Jundishapur University of Medical Sciences.

Item Type: Article
Additional Information: Cited By :6 Export Date: 16 February 2020 Correspondence Address: Sheybani, F.; Department of Infectious Diseases, Imam Reza Teaching Hospital, Mashhad University of Medical SciencesIran
Uncontrolled Keywords: Etiology Pneumonia Streptococcus pneumoniae Tuberculosis bacterial antigen adolescent adult age distribution aged antigen recognition Article bacterial pneumonia blood culture Brucella melitensis brucellosis chickenpox clinical evaluation community acquired pneumonia coughing diarrhea dyspnea female fever geographic distribution health survey hemoptysis hospital admission human immunoaffinity chromatography influenza A Influenza virus A Iran Klebsiella pneumoniae Klebsiella pneumoniae infection Legionella pneumophila legionnaire disease lung hydatid cyst lung mycosis major clinical study male mental disease mixed infection Mucor mucormycosis myalgia Mycobacterium tuberculosis nausea and vomiting observational study pleura fluid pneumococcal infection prognosis serodiagnosis sputum cytodiagnosis sputum level Staphylococcus aureus Staphylococcus infection symptomatology thorax pain very elderly virus pneumonia weight reduction Bacteria (microorganisms) Influenza A virus
Subjects: WC Communicable Diseases
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 05 May 2020 06:53
Last Modified: 05 May 2020 06:53
URI: http://eprints.mums.ac.ir/id/eprint/18998

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