Effect of aqueous extract of crocus sativus L. on morphine-induced memory impairment

Naghibi, S. M. and Hosseini, M. and Khani, F. and Rahimi, M. and Vafaee, F. and Rakhshandeh, H. and Aghaie, A. (2012) Effect of aqueous extract of crocus sativus L. on morphine-induced memory impairment. Advances in Pharmacological Sciences, 2012.

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Abstract

In the present study, the effect of aqueous extracts of saffron on morphine-induced memory impairment was investigated. On the training trial, the mice received an electric shock when the animals were entered into the dark compartment. Twenty-four and forty-eight hours later, the time latency for entering the dark compartment was recorded and defined as the retention trial. The mice were divided into (1) control, (2) morphine which received morphine before the training in the passive avoidance test, (3-5) three groups treated by 50, 150 and 450 mg/kg of saffron extract before the training trial, and (6 and 7) the two other groups received 150 and 450 mg/kg of saffron extract before the retention trial. The time latency in morphine-treated group was lower than control (P < 0.01). Treatment of the animals by 150 and 450 mg/kg of saffron extract before the training trial increased the time latency at 24 and 48 hours after the training trial (P < 0.05 and P < 0.01). Administration of both 150 and 450 mg/kg doses of the extract before retention trials also increased the time latency (P < 0.01). The results revealed that the saffron extract attenuated morphine-induced memory impairment. © 2012 Sayede Maryam Naghibi et al.

Item Type: Article
Additional Information: Cited By :33 Export Date: 16 February 2020 Correspondence Address: Hosseini, M.; Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; email: hosseinim@mums.ac.ir
Uncontrolled Keywords: Crocus sativus extract morphine animal experiment animal model article attenuation controlled study electric shock latent period male memory disorder mouse nonhuman passive avoidance priority journal
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 04 May 2020 09:06
Last Modified: 04 May 2020 09:06
URI: http://eprints.mums.ac.ir/id/eprint/18999

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