Carum induced hypothyroidism: An interesting observation and an experiment

Naghibi, S. M. and Ramezani, M. and Ayati, N. and Zakavi, S. R. (2015) Carum induced hypothyroidism: An interesting observation and an experiment. DARU, Journal of Pharmaceutical Sciences, 23 (1).

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Carum carvi is a widely available herb that has been used as a food additive and as a medication in traditional medicine for many years. Its potential biological effects include analgesic, anti-inflammatory, anti-anxiety and antispasmodic activities. We report a patient with papillary thyroid carcinoma who were under treatment with levothyroxine and experienced an elevated TSH level by ingestion of Carum carvi. TSH level was increased to 60.3 mIU/L with no change in levothyroxine dosage and decreased to normal range after discontinuation of the Carum carvi. Observing this dramatic change in TSH level by carum ingestion, carum carvi capsules was produced and one of the researcher tried the medication on herself with a dose of 40 mg/kg/day. She had a history of hypothyroidism and was taking 100 ugr/day of levothyroxine. TSH was markedly increased 2 weeks after ingestion of Carum carvi and returned to normal range 5 months after discontinuation of it. This case report shows the effect of consumption of Carum carvi in increasing TSH level in hypothyroid patients treating with levothyroxine. The exact mechanism of action of carum carvi remains unknown. © 2015 Naghibi et al.

Item Type: Article
Additional Information: Cited By :6 Export Date: 16 February 2020 CODEN: DJTSF Correspondence Address: Zakavi, S.R.; Nuclear Medicine Research Center, Faculty of Medicine, Mashhad University of Medical SciencesIran; email:
Uncontrolled Keywords: Carum carvi Hypothyroidism Thyroid TSH calcitriol calcium carbonate herbaceous agent iodine 131 levothyroxine thyrotropin thyroxine Achillea adult Article cancer radiotherapy caraway case report constipation coughing dietary supplement drug withdrawal dry skin dyspnea female follow up goiter human lung metastasis medical history morning dosage physical examination plant seed subclinical hyperthyroidism thyroid carcinoma thyroidectomy young adult adverse effects carcinoma Carum chemically induced complication metabolism Thyroid Neoplasms Humans
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 16 May 2020 10:30
Last Modified: 16 May 2020 10:30

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