No evidence of human papilloma virus infection in basal cell carcinoma

Nahidi, Y. and Meibodi, N. T. and Meshkat, Z. and Esmaili, H. and Jahanfakhr, S. (2015) No evidence of human papilloma virus infection in basal cell carcinoma. Indian Journal of Dermatology, 60 (4). pp. 356-359.

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Abstract

Background: Basal cell carcinoma (BCC) is the most common skin cancer among whites, and several risk factors have been discussed in itsdevelopment and progress. Detection of human papilloma virus (HPV) deoxyribonucleic acid (DNA) BCCs in some studies suggests that the virus may play a role in the pathogenesis of this disease. Several molecular studies showed conflicting reports. Aims: The purpose of this study was to investigate the association between HPV and BCC using polymerase chain reaction (PCR). Materials and Methods: HPV DNA detection was done for 42 paraffin-embedded tissue specimens of BCC and 42 normal skin samples around the lesions by PCR using GP5+/GP6+ primers. Results: HPV DNA was not found in any of the 42 samples of BCC, and only one normal skin sample around the lesions was positive for HPV DNA by PCR. Conclusion: In this study, no statistically significant difference was seen between the presence of HPV DNA in BCC and normal skin around the lesion, and HPV is not likely to have an important role in pathogenesis of BCC.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 Correspondence Address: Meibodi, N.T.; Cutaneous Leishmanaisis Research Center, Emam Reza Hospital, Mashhad University of Medical SciencesIran
Uncontrolled Keywords: Basal cell carcinoma human papillomavirus polymerase chain reaction virus DNA adult Article Asian case control study controlled study disease association eyelid female human human tissue major clinical study male neck papillomavirus infection scalp
Subjects: WR Dermatology
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 15 May 2020 21:26
Last Modified: 15 May 2020 21:26
URI: http://eprints.mums.ac.ir/id/eprint/19004

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