The effect of hydro alcoholic nettle (Urtica dioica) extract on oxidative stress in patients with type 2 diabetes: A randomized double-blind clinical trial

Namazi, N. and Tarighat, A. and Bahrami, A. (2012) The effect of hydro alcoholic nettle (Urtica dioica) extract on oxidative stress in patients with type 2 diabetes: A randomized double-blind clinical trial. Pakistan Journal of Biological Sciences, 15 (2). pp. 98-102.

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Abstract

Diabetes type 2 is a metabolic disorder that characterized by hyperglycemia and insulin resistance. Hyperglycemia and impairment of oxidant/antioxidant balance, can increase oxidative stress and increase risk of cardiovascular disease. In the present study, Effects of hydro alcoholic extract of Nettle on oxidative stress in type 2 diabetes were evaluated. Fifty patients (27 men, 23 women) with type 2 diabetes patients were studied. They received 100 mg kg -1 of nettle extract of body weight hydro alcoholic for 8 weeks. At the baseline and end of 8th weeks of intervention blood levels of oxidative stress markers were measured. Data was analyzed by SPSS version 18, p<0.05 was considered significant for all variables. After 8 weeks, Total Antioxidant Capacity (TAC) and Superoxidant Dismutase (SOD) showed a significant increase in the intervention group compared to the control group (p<0.05). The findings showed that the hydro alcoholic extract of nettle has increasing effects on TAC and SOD in patients with type 2 diabetes without no changes in Malondialdehyde (MDA) and Glutathione Peroxides (GPX) after eight weeks intervention. © 2012 Asian Network for Scientific.

Item Type: Article
Additional Information: Cited By :18 Export Date: 16 February 2020 Correspondence Address: Tarighat, A.; Nutrition Research Center, Faculty of Health and Nutrition, Attar Avenue, Golgasht Street, Tabriz, Iran
Uncontrolled Keywords: Antioxidant Complications Free radical Nettie Type 2 diabetes glutathione peroxidase malonaldehyde plant extract superoxide dismutase adult article chemistry clinical trial controlled clinical trial controlled study double blind procedure drug effect female human male metabolism middle aged non insulin dependent diabetes mellitus oxidative stress pathophysiology randomized controlled trial Urtica dioica Antioxidants Diabetes Mellitus, Type 2 Double-Blind Method Humans Malondialdehyde Plant Extracts Urtica
Subjects: WD Nutrition Disease and metabolic diseases
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 15 May 2020 21:35
Last Modified: 15 May 2020 21:35
URI: http://eprints.mums.ac.ir/id/eprint/19007

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