Antioxidant vitamins status in children and young adults undergoing dialysis: A single center study

Naseri, M. and Shahri, H. M. M. and Horri, M. and Rasoli, Z. and Salemian, F. and Jahanshahi, S. and Moeenolroayaa, G. and Pourhasan, M. (2015) Antioxidant vitamins status in children and young adults undergoing dialysis: A single center study. Indian Journal of Nephrology, 25 (4). pp. 206-212.

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Vitamin E and C are well-known antioxidant vitamins. Oxidative stress is common in chronic kidney diseases. We evaluated 43 dialysis subjects prospectively in a cross-sectional survey. Serum vitamin E concentration was checked in all subjects; 37 cases underwent blood sampling for measurement of serum vitamin C. The enrolled subjects consisted of 12 (27.9) peritoneal dialysis (PD) and 25 (58.1) hemodialysis (HD) patients. Six (13.9) patients were switched from PD to HD or vice versa. Serum concentration of vitamin E was normal, low and high in 9 (20.9), 31 (72) and 3 (7.1) patients, respectively. There were no significant differences regarding age, gender, modality and duration of dialysis, and characteristics of dialysis sessions, mean serum blood urea nitrogen, and albumin levels between vitamin E deficient cases with those with normal serum vitamin E concentration (P > 0.05 for all). The serum vitamin C levels were low in 5 (13.5) and normal in 32 (86.5) patients. vitamin C deficiency was more prevalent in HD versus continuous ambulatory peritoneal dialysis patients (P = 0.128). Mean serum vitamin C concentration was higher in patients who were supplemented by vitamin C compared with those who didn't receive the vitamin supplement (P = 0.043). Vitamin E deficiency was a prevalent finding and supplementary vitamin C 30-60 mg/day was sufficient to prevent deficiency. Regular assessments of serum vitamin E level may be needed in dialysis centers.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Naseri, M.; Department of Pediatric Nephrology, Dr. Sheikh Children Hospital, Mashhad University of Medical SciencesIran
Uncontrolled Keywords: Continuous ambulatory peritoneal dialysis hemodialysis Vitamin C Vitamin E albumin alpha tocopherol ascorbic acid adolescent adult alpha tocopherol deficiency Article artificial kidney ascorbic acid deficiency child clinical article controlled study female hemodialysis machine hemodialysis patient human intermethod comparison male peritoneal dialysis peritonitis prevalence urea nitrogen blood level vitamin blood level vitamin supplementation
Subjects: WJ Urogenital System
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 03 May 2020 04:23
Last Modified: 03 May 2020 04:23

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