Glucokinase gene promoter-30G>A polymorphism: A cross-sectional association study with obesity, diabetes Mellitus, hyperlipidemia, hypertension and metabolic syndrome in an Iranian hospital

Oladi, M. R. and Behravan, J. and Hassani, M. and Kassaeian, J. and Sahebkar, A. and Tavallaie, S. and Paydar, R. and Saber, H. and Esmaeili, H. A. and Azimi-Nezhad, M. and Ferns, G. and Ghayour-Mobarhan, M. (2012) Glucokinase gene promoter-30G>A polymorphism: A cross-sectional association study with obesity, diabetes Mellitus, hyperlipidemia, hypertension and metabolic syndrome in an Iranian hospital. Revista de Nutricao, 25 (4). pp. 487-495.

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Abstract

Objective: A-30G>A single nucleotide polymorphism in the promoter region of the glucokinase gene has been previously associated with obesity, insulin resistance and diabetes. The present study aimed to evaluate the association of this polymorphism with obesity and its comorbidities in a population from Northeast Iran. Methods: Five hundred and forty-two subjects aged 18 to 65 years were included in the study and divided into normal (BMI>25, n=220), overweight (25>BMI>30, n=135) and obese (BMI<30, n=187) groups. All subjects were genotyped for the-30G<A polymorphism using the polymerase chain reaction-restriction fragment length polymorphism technique. Results: The genotypes and allele frequencies of the three groups did not differ significantly (p<0.05). When the study population was categorized according to diabetes mellitus, hyperlipidemia, hypertension and metabolic syndrome status, no significant difference in-30G<A genotypes and alleles was found between the subgroups with and without these disorders (p<0.05), apart from a significantly higher frequency of the G allele in the hyperlipidemic vs. non-hyperlipidemic subgroup (p>0.05). Conclusion: The findings of the present study do not support an association between the-30G<A polymorphism and high body mass index in the Iranian population.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 CODEN: RVNUA Correspondence Address: Ghayour-Mobarhan, M.; Mashhad University of Medical Sciences, Biochemistry of Nutrition Research Center, Faculty of Medicine, P.O. Box: 91375-3316, Mashhad, Iran; email: ghayourm@mums.ac.ir
Uncontrolled Keywords: Body mass index Glucokinase Metabolic syndrome Obesity Single nucleotide polymorphism
Subjects: WD Nutrition Disease and metabolic diseases
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 09 May 2020 03:30
Last Modified: 09 May 2020 03:30
URI: http://eprints.mums.ac.ir/id/eprint/19021

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