Effect of ginger on acute and delayed chemotherapy-induced nausea and vomiting: A pilot, randomized, open-label clinical trial

Panahi, Y. and Saadat, A. and Sahebkar, A. and Hashemian, F. and Taghikhani, M. and Abolhasani, E. (2012) Effect of ginger on acute and delayed chemotherapy-induced nausea and vomiting: A pilot, randomized, open-label clinical trial. Integrative Cancer Therapies, 11 (3). pp. 204-211.

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Background. Nausea and vomiting are among the most prevalent and disturbing side effects of chemotherapy. Therefore, there is a need for additional antiemetic agents that could effectively reduce chemotherapy-induced nausea and vomiting (CINV), whether alone or in combination with current standard therapies. Since clinical data on the effectiveness of ginger in patients with advanced breast cancer is lacking, the present study aimed to evaluate the effects of ginger against both acute and delayed forms of CINV in a population with advanced breast cancer as the main malignancy. Methods. In this pilot, randomized, open-label clinical trial, 100 women (mean age = 51.83 ± 9.18 years) with advanced breast cancer who were initially assigned to standard chemotherapy protocol with docetaxel, epirubicin, and cyclophosphamide (the TEC regimen) were randomized to receive ginger (1.5 g/d in 3 divided doses every 8 hours) plus standard antiemetic regimen (granisetron plus dexamethasone; the ginger group) or standard antiemetic regimen alone (control group). The duration of treatment with ginger was specified to 4 days from the initiation of chemotherapy. Prevalence, score, and severity of nausea, vomiting, and retching were assessed using a simplified form of Rhodes index in the first 6 hours, between 6 to 24 hours, and days 2, 3, and 4 postchemotherapy. Results. A significantly lower prevalence of nausea was observed in the ginger group during 6 to 24 hours postchemotherapy. Despite this effect, no other significant additional benefit from ginger (1.5 g/d) was observed against prevalence or severity of nausea, vomiting, and retching in any of the assessed periods. Conclusion. Addition of ginger (1.5 g/d) to standard antiemetic therapy (granisetron plus dexamethasone) in patients with advanced breast cancer effectively reduces the prevalence of nausea 6 to 24 hours postchemotherapy. However, there is no other additional advantage for ginger in reducing prevalence or severity of acute or delayed CINV. © The Author(s) 2012.

Item Type: Article
Additional Information: Cited By :51 Export Date: 16 February 2020 CODEN: ICTNA Correspondence Address: Panahi, Y.; Research Center of Chemical Injuries, Baqiyatallah University of Medical Sciences, Molla-Sadra Street, Tehran, Iran; email: yunespanahi@yahoo.com
Uncontrolled Keywords: breast cancer chemotherapy-induced nausea and vomiting (CINV) cyclophosphamide docetaxel epirubicin ginger Rhodes index dexamethasone ginger extract granisetron adult aged article cancer combination chemotherapy chemotherapy induced nausea and vomiting controlled study disease severity female follow up heartburn human major clinical study nausea open study pilot study prevalence priority journal randomized controlled trial retching self report treatment duration vertigo vomiting Antiemetics Antineoplastic Combined Chemotherapy Protocols Breast Neoplasms Drug Therapy, Combination Etoposide Humans Middle Aged Pilot Projects Severity of Illness Index Taxoids Time Factors
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 04 May 2020 09:25
Last Modified: 04 May 2020 09:25
URI: http://eprints.mums.ac.ir/id/eprint/19028

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