A randomized comparative trial on the therapeutic efficacy of topical aloe vera and calendula officinalis on diaper dermatitis in children

Panahi, Y. and Sharif, M. R. and Sharif, A. and Beiraghdar, F. and Zahiri, Z. and Amirchoopani, G. and Marzony, E. T. and Sahebkar, A. (2012) A randomized comparative trial on the therapeutic efficacy of topical aloe vera and calendula officinalis on diaper dermatitis in children. The Scientific World Journal, 2012.

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Introduction. Diaper dermatitis (DD) is a common inflammatory disorder among children and infants. The objective of the present randomized and double-blind trial was to compare the therapeutic efficacies of Aloe vera cream and Calendula officinalis ointment on the frequency and severity of DD in children. Methods. Sixty-six infants with DD (aged 3 years) were randomized to receive either Aloe cream (n = 32) or Calendula ointment (n = 34). Infants were treated with these drugs 3 times a day for 10 days. The severity of dermatitis was graded at baseline as well as at the end of trial using a 5-point scale. The adverse effects of study medications were assessed during the trial. Results. Although improvement in the severity of DD was observed in both treatment groups (P 0.001), patients receiving Calendula ointment had significantly fewer rash sites compared to Aloe group (P = 0.001). No adverse effect was reported from either of the medications. Discussion. The evidence from this study suggests that topical Aloe and in particular Calendula could serve as safe and effective treatment for the treatment of diaper dermatitis in infants. Copyright 2012 Yunes Panahi et al.

Item Type: Article
Additional Information: Cited By :29 Export Date: 16 February 2020 Correspondence Address: Panahi, Y.; Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, P.O. Box 19945-581, Tehran, Iran; email: yunespanahi@yahoo.com
Uncontrolled Keywords: Aloe vera extract calendula officinalis extract plant extract unclassified drug olive oil vegetable oil absence of side effects Aloe vera article child childhood disease controlled study cream diaper dermatitis disease severity double blind procedure drug efficacy drug safety female human infant infant disease major clinical study male marigold medicinal plant ointment preschool child randomized controlled trial rash treatment outcome Aloe Calendula chemistry clinical trial comparative study controlled clinical trial drug administration emulsion flower hospitalization intradermal drug administration phytotherapy prevalence Calendula officinalis Administration, Cutaneous Child, Preschool Diaper Rash Double-Blind Method Drug Administration Schedule Emulsions Flowers Humans Ointments Plant Extracts Plant Oils Plants, Medicinal Severity of Illness Index
Subjects: WS Pediatrics
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 16 May 2020 11:06
Last Modified: 16 May 2020 11:06
URI: http://eprints.mums.ac.ir/id/eprint/19030

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