Chronic myeloid leukemia in patient with local recurrence colon cancer: A case report

Payandeh, M. and Sadeghi, E. and Sadeghi, M. and Falsafi, F. and Madani, S. H. (2015) Chronic myeloid leukemia in patient with local recurrence colon cancer: A case report. International Journal of Cancer Research, 11 (4). pp. 197-200.

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Abstract

Chronic Myeloid Leukemia (CML) is a chronic disease that about 50 of patients are more than 60 years old and about 50 of patients are asymptomatic. In this study, It is reported that, a case of CML after colon cancer chemotherapy in a 52 year old male from Iran who diagnosed locally advanced poorly differentiation colon adenocarcinoma with extension to prostate for him that had undergone to chemotherapy induction, then chemoradiation with surgery for mid-rectal cancer in the follow-up with picture of local recurrence and rectovesical-fistula. His first regimen in induction chemotherapy phase been oxaliplatin plus capecitabine and follow with chemoradiation for one month. The KRAS was mutation for the patient. He treated with combination of capecitabine with bevacizumab. After new progression he treated with Xeloda+irinotecan regimen. In routine follow-up in complete blood count analysis, It was found that shift to left with immature granulocytopoietic forms. Analysis by RT-PCR peripheral blood showed that Philadelphia chromosome was positive, so CML was diagnosed for him and was add imatinib to his treatment policy. Combination of oxaliplatin and irinotecan can be carcinogenic even they can probably create secondary hematological malignancy like CML and also irradiation can be other risk factor in patients with colorectal cancer following chemotherapy. © 2015 Academic Journals Inc.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 Correspondence Address: Sadeghi, E.; Medical Biology Research Center, Kermanshah University of Medical SciencesIran
Uncontrolled Keywords: Chemotherapy CML Colon cancer Radiotherapy bevacizumab capecitabine imatinib irinotecan oxaliplatin adult Article blood cell count cancer recurrence case report chemoradiotherapy chronic myeloid leukemia colon surgery diarrhea gene mutation human induction chemotherapy male middle aged multiple cycle treatment oncogene K ras Philadelphia chromosome positive cell reverse transcription polymerase chain reaction
Subjects: WI Digestive System
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 16 May 2020 11:57
Last Modified: 16 May 2020 11:57
URI: http://eprints.mums.ac.ir/id/eprint/19032

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