Anti-cancer properties of a sesquiterpene lactone-bearing fraction from Artemisia khorassanica

Rabe, S. T. and Emami, S. A. and Iranshahi, M. and Rastin, M. and Tabasi, N. and Mahmoudi, M. (2015) Anti-cancer properties of a sesquiterpene lactone-bearing fraction from Artemisia khorassanica. Asian Pacific Journal of Cancer Prevention, 16 (3). pp. 863-868.

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Abstract

Background: Artemisia species are important medicinal plants throughout the world. The present in vitro study, using a sesquiterpene lactone-bearing fraction prepared from Artemisia khorassanica (SLAK), sought to investigate anti-cancer properties of this plant and elucidate potential underlying mechanisms for the effects. Materials and Methods: Anti-cancer potential was evaluated by toxicity against human melanoma and fibroblast cell lines. To explore the involved pathways, pattern of any cell death was determined using annexin-V/PI staining and also the expression of Bax and cytochrome c was investigated by Western blotting. Results: The results showed that SLAK selectively caused a concentration-related inhibition of proliferation of melanoma cells that was associated with remarkable increase in early events and over-expression of both Bax and cytochrome c. Conclusions: The current experiment indicates that Artemisia may have anti-cancer activity. We anticipate that the ingredients may be employed as therapeutic candidates for melanoma.

Item Type: Article
Additional Information: Cited By :4 Export Date: 16 February 2020 Correspondence Address: Mahmoudi, M.; Immunology Research Center, Bu-Ali Research Institute, School of Medicine, Mashhad University of Medical ScienceIran
Uncontrolled Keywords: Apoptosis Artemisia khorassanica Bax Cytochrome c Melanoma cell line caspase lactone plant extract sesquiterpene Artemisia cell culture cell cycle cell proliferation chemistry cytology drug effects fibroblast human melanoma metabolism pathology plant structures Western blotting Blotting, Western Caspases Cells, Cultured Cytochromes c Fibroblasts Humans Lactones Plant Components, Aerial Plant Extracts Sesquiterpenes
Subjects: QV pharmacology
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 15 May 2020 13:39
Last Modified: 15 May 2020 13:39
URI: http://eprints.mums.ac.ir/id/eprint/19038

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