Cinnamon extract supplementation improves inflammation and oxidative stress induced by acrylamide: An experimental animal study

Haidari, Fatemeh and Mohammadshahi, Majid and Abiri, Behnaz and Zarei, Mehdi and Fathi, Mojdeh (2020) Cinnamon extract supplementation improves inflammation and oxidative stress induced by acrylamide: An experimental animal study. Avicenna Journal of Phytomedicine, 10 (3). pp. 243-252.

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Abstract

Objective: Toxic effects of acrylamide on body organs incline researches to prevent or decrease these effects. The objective of the present study was to evaluate the effects of cinnamon extract (CE) supplementation on inflammation and oxidative stress induced by acrylamide in rats. Materials and Methods: Thirty two rats were divided into four groups as follow 1) The control group received distilled water, 2) Acrylamide- intoxicated group was administrated with 35 ml/kg/day acrylamide for two weeks, 3) Acrylamide- intoxicated rats treated with CE 250 mg/kg/day for 28 days, and 4) Acrylamide- intoxicated rats treated with CE 500 mg/kg day for 28 days. Fasting blood sample was obtained for subsequent analysis. Results: The results showed that acrylamide- intoxicated group had significantly higher levels of malondialdehyde, tumor necrosis factor alpha, high sensitive C reactive protein, leptin and alanine transaminase (p0.05). Conclusion: This study suggests that cinnamon extract may potentially be effective as a dietary source of bioactive compounds for managing acrylamide intoxication.

Item Type: Article
Uncontrolled Keywords: Cinnamon extract,Acrylamide,Oxidative stress,Liver Enzyme,Inflammation
Subjects: WB Practice of Medicine
QT physiology
QV pharmacology
Divisions: Journals > Avicenna J Phytomedicine
Depositing User: ajp ajp
Date Deposited: 02 May 2020 08:42
Last Modified: 02 May 2020 08:42
URI: http://eprints.mums.ac.ir/id/eprint/19159

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