Preparation and study of the inhibitory effect of nano-niosomes containing essential oil from artemisia absinthium on amyloid fibril formation

Ansari, Mojtaba and Eslami, Hossein (2020) Preparation and study of the inhibitory effect of nano-niosomes containing essential oil from artemisia absinthium on amyloid fibril formation. Nanomedicine Journal, 7 (3). pp. 243-250.

[img] Text
NMJ_Volume 7_Issue 3_Pages 243-250.pdf

Download (774kB)
Official URL: http://nmj.mums.ac.ir/article_15573.html

Abstract

Objective(s): Artemisia absinthium is an aromatic, perennial small shrub that shows multiple medical benefits, including anticancerous, neuroprotective, antifungal, hepatoprotective, antidepressant and antioxidant properties. One of the effective approaches to treat Alzheimer�s disease is targeting amyloid aggregation by antiamyloid drugs. In the current research study, an excellent grouping of niosomal, lipid nano-carriers drugs containing artemisia absinthium is advanced and characterized to inhibit amyloid aggregation.Materials and Methods: Niosomal vesicles were made employing phosphatidylcholine, span 60, cholesterol and DSPE-PEG2000 by the thin-film method. Then artemisia absinthium was loaded into the niosomes. Their physico-chemical attributes were analyzed utilizing Zeta-Sizer, FTIR, and SEM, and the amount of drug release was measured at 37° C. Finally, the inhibitory effect of artemisia absinthium that loaded niosomal vesicles on the aggregation of amyloid-β peptides was investigated using Thio�avin T �uorescence measurements and atomic force microscopy.Results: Niosomes containing artemisia absinthium have a size of 174±2.56nm, the encapsulation efficiency of 66.73, zeta potential of -26.5±1/42 mV and polydispersity index (PDI) of 0.373±0/02. The release of the drug is controlled in this nano-carrier and FTIR and SEM investigations showed that the drug and nano-carrier did not interact and their particles had a spherical structure. In the end, the inhibitory effect of artemisia absinthium that loaded niosomal vesicles on the aggregation of amyloid-β peptides was examined and confirmed through Thio�avin T �uorescence measurements and atomic force microscopy.Conclusion: Meanwhile, the findings of the current study, confirm the appropriate physicochemical features of the system, a slow-release system, show that this nano-carrier inhibits amyloid aggregation, thus, the nano-niosomes containing essential oil from artemisia absinthium has the capability to preclude amyloid development.

Item Type: Article
Uncontrolled Keywords: Alzheimer�s disease,Amyloid-β aggregation,Niosome,Artemisia absinthium,Drug Delivery
Subjects: QT physiology
Divisions: Journals > Nanomedicine Journal
Depositing User: nmj nmj
Date Deposited: 13 Jun 2020 04:31
Last Modified: 13 Jun 2020 04:31
URI: http://eprints.mums.ac.ir/id/eprint/19269

Actions (login required)

View Item View Item