Synthesis of a novel PEGylated colon-specific azo-based 4- aminosalicylic acid prodrug

Sadeghi, Fatemeh and Eidizade, Atie and Saremnejad, Farinaz and Hadizadeh, Farzin and Khodaverdi, Elham and Akhgari, Abbas (2020) Synthesis of a novel PEGylated colon-specific azo-based 4- aminosalicylic acid prodrug. Iranian Journal of Basic Medical Sciences, 23 (6). pp. 781-787.

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Abstract

Objective(s): 4-aminosalicylic acid (4-ASA) is an isomer of mesalazine that has recently been shown to be effective against inflammatory bowel disease (IBD), and more specifically, ulcerative colitis. However, the majority of orally administered 4-ASA is readily and extensively absorbed from the stomach and small intestine, so only a small amount is transported to the colon. A mutual ester and azo prodrug of 4-ASA was synthesized with polyethylene glycol (PEG) and dimethylaniline, respectively , to overcome this issue. Materials and Methods: The 4-ASA prodrug was synthesized via a two-step process and then characterized by 1H-NMR. The stability of the prodrug was evaluated in simulated gastric fluid (pH 1.2). Furthermore, the in vitro release profiles of the drug conjugate was evaluated at pH 1.2, as well as pH 6.8 in the absence or presence of rat cecal content. Results: The prepared prodrug was stable at pH 1.2, indicating that it could be protected from the acidic environment of the stomach. Also, the results of drug release at pH 6.8 showed that the amount of 4-ASA released was 63 within 12 hr in the absence of rat cecal content, while in the presence of rat cecal content, 97 of 4-ASA was released from the prodrug in 6 hr. Conclusion: Overall, the synthesized PEGylated azo-based 4-ASA prodrug could be a potential candidate for targeted drug delivery to the inflamed gut tissue in IBD.

Item Type: Article
Uncontrolled Keywords: 4-aminosalicylic acid,Azo linkage,IBD,PEGylated prodrug,Prodrug
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 23 Jun 2020 05:50
Last Modified: 23 Jun 2020 05:50
URI: http://eprints.mums.ac.ir/id/eprint/19289

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