Evaluation of CD133 and CD56/NCAM expression in Wilms tumor and their association with prognostic factors

Jafarian, Amir Hossein and Zaboli Nejad, Nona and Mohamadian Roshan, Nema and Hashemi, Sara and Gharib, Masoumeh (2020) Evaluation of CD133 and CD56/NCAM expression in Wilms tumor and their association with prognostic factors. Iranian Journal of Basic Medical Sciences, 23 (7). pp. 853-857.

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Abstract

Objective(s): To validate certain markers for cancer stem cell populations and their clinical importance in Wilms tumor (WT)Materials and Methods: Immunohistochemical study for CD133 and CD56/NCAM was performed on forty-six cases of WT that were diagnosed between 1999 and 2015, and the association of these markers with survival and prognostic factors was analyzed. Results: Thirty-four (73.9) of WTs were positive for CD133 and thirty-nine (84.8) were positive for CD56/NCAM. A significant positive correlation between CD133 and CD56/NCAM expression and the National Wilms Tumor Stage (NWTS) and death was found. Moreover, overall survival time was significantly correlated with CD133 and CD56/NCAM H-score, NWTS stage, and death. Conclusion: It seems that CD133 and CD56/NCAM expressions can be used as strong prognostic parameters for the survival of patients with WT and can be used to predict WT patients’ stage. Moreover, their targeted therapies can abolish cancer stem cells in children with recurrent tumors.

Item Type: Article
Uncontrolled Keywords: CD133,immunohistochemistry,Neural cell adhesion molecules,Stem cells,Wilms tumor
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 16 Jun 2020 07:24
Last Modified: 16 Jun 2020 07:24
URI: http://eprints.mums.ac.ir/id/eprint/19298

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