Phytoremedial effect of Withania somnifera against arsenic-induced testicular toxicity in Charles Foster rats

Kumar, Arun and Kumar, Ranjit and Samuir Rahman, Mohammad and Iqubal, Mohammad Asif and Anand, Gautam and Kumar Niraj, Pintoo and Ali, Mohammad (2015) Phytoremedial effect of Withania somnifera against arsenic-induced testicular toxicity in Charles Foster rats. Avicenna Journal of Phytomedicine, 5 (4). pp. 355-364.

[img]
Preview
Text
AJP_Volume 5_Issue 4_Pages 355-364.pdf

Download (808kB) | Preview
Official URL: http://ajp.mums.ac.ir/article_4353.html

Abstract

Objective: The main objective of the current study was to observe the ameliorative effect of Withania somnifera on arsenic-induced testicular toxicity by exploring the crucial parameters such as sperm counts, sperm motility, hormonal assay and lipid peroxidation including histopathology. Materials and Methods: In the present study, arsenic in the form of sodium arsenite was administered orally to male Charles Foster rats for 45 days. Thereafter, ethanolic root extract of Withania somnifera was administered for 30 days to observe its ameliorative effect on male reproductive system. Results: The study revealed that after administration of sodium arsenite, there was a decrease in the sperm counts and sperm motility accompanied by an increased incidence of sperm abnormalities and hormonal imbalance leading to infertility. However, after administration of Withania somnifera, there was significant reversal in the parameters denoting that it not only possesses antioxidant and rejuvenating property but also maintains the cellular integrity of testicular cells leading to normal functioning of it. Conclusion: The study concludes that Withania somnifera possesses phytoremedial effect. It is one of the best antidotes against arsenic-induced reproductive toxicity.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Avicenna J Phytomedicine
Depositing User: ajp ajp
Date Deposited: 21 Sep 2017 13:33
Last Modified: 21 Sep 2017 13:33
URI: http://eprints.mums.ac.ir/id/eprint/2044

Actions (login required)

View Item View Item