The Relationship between Serum Uric Acid and Severity of Chronic Obstructive Pulmonary Disease (COPD)

Vafaei, Atefe and Saremi, Zeinab and Mortazavi Moghaddam, Sayyed Gholamreza and Javid Arabshahi, Zahra (2017) The Relationship between Serum Uric Acid and Severity of Chronic Obstructive Pulmonary Disease (COPD). Journal of Cardio-Thoracic Medicine, 5 (3). pp. 181-186.

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Introduction: Some evidence exists about the possible relationship between the serum uric acid (UA) and exacerbation of the chronic obstructive pulmonary disease (COPD). Present study intended to compare the COPD-related variables and the one-year outcome between the two groups of patients with the high and low UA. Material and Methods: This cohort study consisted of 112 patients with COPD exacerbation. The participants were categorized into low (i.e., Afterwards, the patients were followed up for one year and some other variables such as taking oral antibiotic for respiratory infections, admission to hospital or ICU due to COPD exacerbation, and survival were documented monthly. Results: The mean serum level of creatinine was significantly higher in the high UA group (1.1±0.4 mg/dL) than the low UA group (1.01±0.1 mg/dL) (P=0.02). No significant difference was observed between the two groups regarding the GOLD classification, FEV1, oxygen saturation, pCO2, and echocardiographic indices. In the one-year follow-up, 42 cases (82.4) of the high UA group and 39 patients (63.9) of the low UA group reported taking oral antibiotics, which was indicative of a significant difference (P=0.03). Hospital admission was likewise significantly higher in the high UA group (30 patients, 58.8) than in the low UA group (23 cases, 37.7) (P= 0.03). Conclusion: Those patients with the UA level of � 6.5 mg/dL experienced more hospital admission and were more likely to take oral antibiotics for respiratory infections during a year. However, UA did not correlate with FEV1 or COPD severity.

Item Type: Article
Subjects: WO Surgery
Divisions: Journals > J Cardio-Thoracic Medicine
Depositing User: jctm jctm
Date Deposited: 04 Sep 2017 14:55
Last Modified: 04 Sep 2017 14:55

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