Anti-inflammatory, Analgesic and Antiulcer properties of Porphyra vietnamensis

Bhatia, Saurabh and Sharma, Kiran and Sharma, Ajay and Nagpal, Kalpana and Bers, Tanmoy (2015) Anti-inflammatory, Analgesic and Antiulcer properties of Porphyra vietnamensis. Avicenna Journal of Phytomedicine, 5 (1). pp. 69-77.

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Abstract

Objectives: Aim of the present work was to investigate the anti-inflammatory, analgesic and antiulcer effects of red seaweed Porphyra vietnamensis (P. vietnamenis). Materials and Methods: Aqueous (POR) and alcoholic (PE) fractions were successfully isolated from P. vietnamenis. Further biological investigations were performed using a classic test of paw edema induced by carrageenan, writhing induced by acetic acid, hot plate method and naproxen induced gastro-duodenal ulcer. Results: Among the fractions POR showed better activity. POR and PE significantly (p < 0.05) reduced carrageenan induced paw edema in a dose dependent manner. In the writhing test POR significantly (p < 0.05) reduced abdominal writhes than PE. In hot plate method POR showed better analgesic activity than PE. POR showed comparable ulcers reducing potential (p<0.01) to that of omeprazole, and has more ulcer reducing potential then PE. Conclusions: The results of this study demonstrated that P. vietnamenis aqueous fraction possesses biological activity that is close to the standards taken for the treatment of peripheral painful or/and inflammatory and ulcer conditions.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Avicenna J Phytomedicine
Depositing User: ajp ajp
Date Deposited: 21 Sep 2017 15:01
Last Modified: 21 Sep 2017 15:01
URI: http://eprints.mums.ac.ir/id/eprint/2228

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