Renoprotective effect of hydroalcoholic extract of Rheum ribes root in diabetic female rats

Hamzeh, Shokri and Farokhi, Farah and Heydari, Reza and Manaffar, Ramin (2014) Renoprotective effect of hydroalcoholic extract of Rheum ribes root in diabetic female rats. Avicenna Journal of Phytomedicine, 4 (6). pp. 392-401.

[img]
Preview
Text
AJP_Volume 4_Issue 6_Pages 392-401.pdf

Download (998kB) | Preview
Official URL: http://ajp.mums.ac.ir/article_3371.html

Abstract

Objective: Medical plants, as rich sources of natural antioxidants with antidiabetic effects, are used worldwide to diminish a variety of symptoms and many diseases. R. ribes L., which belongs to the family of polygonaceae, can provide symptomatic relief and assist in the prevention of the secondary complications of the diabetes. Material and Methods: 36 female adult rats were randomly divided into 6 groups of 6. Normal Control groups treated with normal saline. Positive control groups treated with hydroalcohlic extract of R. ribes root (150 mg/kg) daily by gavages for 4 consecutive weeks. Diabetes was inducedby injection of 120 mg/kg alloxan monohydrate intraperitoneally. Two diabetic groups were treated with different doses of R. ribes root extract. The sixth diabetic groups were treated with glibenclamide (0.6 mg/kg). At the end of 28 days, blood samples were collected and their kidney tissues were processed for light microscopy. Results: The results showed that hydro-alcoholic extract of R. ribes decreased the level of glucose, cholesterol, triglyceride, urea and creatinine in diabetic rats (p<0.05) in compared with diabetic rats, while the level of HDL increased at the same group (p<0.05). Histopathological changes of kidney samples were comparable with respective control. In diabetic rats, kidney sections showed atrophy of glomerular capillaries with increased Bowman's space and acute tubular necrosis. The groups that were treated with R. ribes root were improved towards normal condition. Conclusion: It is interesting to note that hydroalcohlic extract of R. ribes root improves renal dysfunction in alloxan-induced diabetic rats through controlling blood glucose and renal protective effects.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Avicenna J Phytomedicine
Depositing User: ajp ajp
Date Deposited: 21 Sep 2017 15:20
Last Modified: 21 Sep 2017 15:20
URI: http://eprints.mums.ac.ir/id/eprint/2252

Actions (login required)

View Item View Item