Simulation of metabolism-based herb-drug interaction: towards safe and efficacious use of NIPRD-AM1

Adzu, Bulus and Mustapha, Kudirat Bola and Masimirembwa, Collen and Obodozie, Obiageri and Abdullahi Kirim, Rukaiyatu and Gamaniel, Karniyus Shingu (2013) Simulation of metabolism-based herb-drug interaction: towards safe and efficacious use of NIPRD-AM1. Avicenna Journal of Phytomedicine, 3 (3). pp. 201-204.

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Abstract

Objective: To evaluate the effect of NIPRD-AM1 on CYP3A4 in order to generate clinically significant data for its safe and efficacious use. Materials and Methods: NIPRD-AM1 is a phytomedicine developed from aqueous root extracts of Nauclea latifolia Smith (Rubiaceae) for the treatment of uncomplicated malaria. The effect of NIPRD-AM1 on CYP3A4 was measured with and without the addition of NIPRD-AM1, by testing different concentrations of the product at 37 °C in reactive mixtures with ketoconazole (2.5 µM) as the positive control. Results: Results showed a very low IC50 value of 0.01 mg/ml similar to that of ketoconazole (0.016 mg/ml). Conclusion: Metabolic processes of NIPRD-AM1 are likely to inhibit CYP3A4, with potential implication on drugs that are CYP3A4 substrates. This is a promising approach for guidance towards the safe and efficacious use of NIPRD-AM1.

Item Type: Article
Subjects: QU Biochemistry
QV pharmacology
Divisions: Journals > Avicenna J Phytomedicine
Depositing User: ajp ajp
Date Deposited: 23 Sep 2017 14:21
Last Modified: 23 Sep 2017 14:21
URI: http://eprints.mums.ac.ir/id/eprint/2435

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