Effect of aqueous fraction of Rosa damascena on ileum contractile response of guinea pigs

Dolati, Karim and Rakhshandeh, Hassan and Shafei, Mohammad Naser (2013) Effect of aqueous fraction of Rosa damascena on ileum contractile response of guinea pigs. Avicenna Journal of Phytomedicine, 3 (3). pp. 248-253.

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Objective: The use of drugs with herbal origin is increasing for treatment of gastrointestinal (GI) disorders. Rosa damascena (R. damascena) is a well-known plant suggested to have beneficial effect on GI system. In this study, the effect of aqueous fraction of R. damascena on the contractionsofisolated guinea pig ileum was investigated. Materials and Methods: Aqueous fraction of plant was obtained from ethanolic extract after ethyl acetate and n-butanol fractions were discarded. To evaluate effect of this fraction on ileum contraction, guinea pig ileum was removed and mounted on organ bath and its contraction was recorded. Effect of various concentrations (0.66, 0.83, and 1.3 mg/ml) of aqueous fraction on ileum contraction in comparison with Ach in presence and absense of atropine, a muscarinic antagonist of cholinergic, was evaluated. The response of ileum to 1 µg/ml of acetylcholine was considered as 100 response. Results:Our results showed that aqueous fractions of R. damascena dose-dependently increased basal guinea pigs ileum contractions (pConclusion: It is concluded that aqueous fraction of R. damascena has mild excitatory effect on ileum contraction and this fraction may be beneficial as a mild laxative agent.

Item Type: Article
Subjects: WE Musculoskeletal system
W General medicine- Health professions
Divisions: Journals > Avicenna J Phytomedicine
Depositing User: ajp ajp
Date Deposited: 23 Sep 2017 14:30
Last Modified: 23 Sep 2017 14:30
URI: http://eprints.mums.ac.ir/id/eprint/2441

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