Comparative proteome analysis of human esophageal cancer and adjacent normal tissues

Yazdian–Robati, Rezvan and Ahmadi, Homa and Matbou Riahi, Maryam and Lari, Parisa and Aledavood, Seyed Amir and Rashedinia, Marzieh and Abnous, Khalil and Ramezani, Mohammad (2017) Comparative proteome analysis of human esophageal cancer and adjacent normal tissues. Iranian Journal of Basic Medical Sciences, 20 (3). pp. 265-271.

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Official URL: http://ijbms.mums.ac.ir/article_8354.html

Abstract

Objective(s): Ranking as the sixth commonest cancer, esophageal squamous cell carcinoma (ESCC) represents one of the leading causes of cancer death worldwide. One of the main reasons for the low survival of patients with esophageal cancer is its late diagnosis. Materials and Methods: We used proteomics approach to analyze ESCC tissues with the aim of a better understanding of the malignant mechanism and searching candidate protein biomarkers for early diagnosis of esophageal cancer. The differential protein expression between cancerous and normal esophageal tissues was investigated by two-dimensional polyacrylamide gel electrophoresis (2D-PAGE). Then proteins were identified by matrix-assisted laser desorption/ ionization tandem time-of-flight mass spectrometry (MALDI-TOF/TOF-MS) and MASCOT web based search engine. Results:We reported 4 differentially expressed proteins involved in the pathological process of esophageal cancer, such as annexinA1 (ANXA1), peroxiredoxin-2 (PRDX2), transgelin (TAGLN) andactin-aortic smooth muscle (ACTA2). Conclusion: In this report we have introduced new potential biomarker (ACTA2). Moreover, our data confirmed some already known markers for EC in our region.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 23 Sep 2017 00:36
Last Modified: 23 Sep 2017 00:36
URI: http://eprints.mums.ac.ir/id/eprint/2520

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