The frequency of blaIMP and blaVIM carbapenemase genes in clinical Isolates of pseudomonas aeruginosa in Isfahan medical centers

Rahimzadeh Torabi, Ladan and Doudi, Monireh and Golshani, Zeynab (2016) The frequency of blaIMP and blaVIM carbapenemase genes in clinical Isolates of pseudomonas aeruginosa in Isfahan medical centers. medical journal of mashhad university of medical sciences, 59 (3). pp. 139-147.

[img]
Preview
Text
MJMS_Volume 59_Issue 3_Pages 139-147.pdf

Download (587kB) | Preview
Official URL: http://mjms.mums.ac.ir/article_7714.html

Abstract

Introduction:This study aimed to investigate the discovery of antibiotic resistance in isolates of Pseudomonas aeruginosa and antibiotic susceptibility patterns and also, identify the gene encoding beta-lactamase in the isolated strains, isolated from nosocomial infections in patients admitted to the hospitals of Isfahan province. Methods:In this cross-sectional study, 51 isolates of Pseudomonas aeruginosa were collected from patients in various hospitals and clinical laboratories in North, South and Central Isfahan. Then, antibiotic susceptibility of isolates was determined, using standard methods and disk diffusion method. The carbapenemase genes of blaVIM and blaIMP were detected by PCR test. Results: Clinical isolates of Pseudomonas aeruginosa were most resistant to ciprofloxacin (96/08 ), carbenicillin (92/16), imipenem (80 ), ampicillin (72/55) and nitrofurantoin (78/43), respectively. On the other hand, among the highest rates of infection by Pseudomonas aeruginosa were wounds, by the rate of 33/33 . Of 51 cases with drug resistance, 32 strains (63) had beta-lactamase-producing blaIMP gene , while none of the gene were blaVIM. Conclusion: The results of this study showed that resistance to antibiotics among strains of Pseudomonas aeruginosa isolated from patients, were prevalent. Therefore, fast and precise evaluation of antibiotic resistance is necessary, because the strains producing beta-lactamase, among hospital strains are on the rise.

Item Type: Article
Subjects: QW Microbiology and Immunology
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 23 Sep 2017 03:32
Last Modified: 23 Sep 2017 03:32
URI: http://eprints.mums.ac.ir/id/eprint/2580

Actions (login required)

View Item View Item