Effect of Gelatin Sponge and Tranexamic Acid M.rinses on Prevention of Bleeding after Dental Extraction in Patients Taking Warfarin

Peymani Mojaver, Ali and Soltani, Maryam and Bakhshi, Hamid (2011) Effect of Gelatin Sponge and Tranexamic Acid M.rinses on Prevention of Bleeding after Dental Extraction in Patients Taking Warfarin. Journal of Mashhad Dental School, 35 (1). pp. 17-22.

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Abstract

Introduction: Management of postoperative bleeding in patients receiving warfarin, has always been one of the most challenges for dentists. Cessation in using warfarin 2-3 days before tooth extraction is one of the methods for preventing bleeding in these patients, but it may increase the risk of thromboembolism. The aim of this study was to use localized haemostatic drugs instead including gelatin sponge and tranexamic acid mouthwash. Materials & Methods: In this clinical trial study, 22 patients who were currently receiving warfarin with INR range of 2-4 were selected. For each patient 3 teeth were extracted in several times. After extraction of each tooth, Gelatin sponge, Tranexamic acid 4/8 mouth wash and sterile gauze (without any haemostatic drug) were used.Tendency of bleeding in 66 teeth, 2 and 24 hours after extraction was checked. No suture was used for any patient. Data were analyzed with descriptive statistics (frequency and average) and Chi-square and Fisher's exact tests. Results: Rate of bleeding in three groups were measured: Gelatin sponge: 9.1, Tranexamic acid 4.8 mouthwash: zero and sterile gauze (without any haemostatic drug): 27.3 . Conclusions: In patients treated with warfarin, interruption in use of warfarin for tooth extraction is not needed. Local haemostasis with tranexamic acid 4.8 mouthwash without any suture is sufficient.

Item Type: Article
Subjects: WU Dentistry. Oral surgery
Divisions: Journals > Journal of Mashhad Dental School
Depositing User: jmds jmds
Date Deposited: 23 Sep 2017 14:14
Last Modified: 23 Sep 2017 14:14
URI: http://eprints.mums.ac.ir/id/eprint/2705

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