A Comparison of Oral High Dose Amoxicillin with Parenteral Penicillin in Treatment of Acute Oral Infections

JavadzadehBolouri, Abbas and Babazadeh, Faramrz and Shiehzadeh, Masoud and DalirSani, Zohreh (2009) A Comparison of Oral High Dose Amoxicillin with Parenteral Penicillin in Treatment of Acute Oral Infections. Journal of Mashhad Dental School, 33 (3). pp. 197-206.

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Introduction: Regarding to the difficulties and side effects of parenteral penicillin and considering the positive effects of high dose oral amoxicillin on acute odontogenic infections based on a previous pilot study, we decided to look for a practical and useful alternative treatment for parenteral penicillin. This study was planned to compare therapeutic effect of oral high dose amoxicillin with parenteral penicillin in treatment of acute odontogenic infections. Materials & Methods: In this clinical trial study, approved by ethical committee of Mashhad University of Medical Sciences, 56 patients with acute odontogenic infection were randomly divided into 2 groups. After obtaining informed consents, Patients in control and case groups were treated, respectively, by parenteral penicillin G and oral amoxicillin (2g three times a day). All of the patients were visited after 24 hour, 48 hour and 1 week intervals and the body temperature, pain intensity, size of the swelling and skin redness were recorded. Our criteria for improvement and responding to the treatment in this study were absence of fever, pain and redness and maximum reduction of swelling. Data were analyzed by Mann-Whitney and Fisher's exact tests through SPSS software (P=0.05). Results: 25 patients of control and 26 patients of case group were recovered (after 1 week) and no significant difference was found between the two groups (X2=0/0219, P=0.0639). Conclusion: Our study showed that high dose oral amoxicillin was as effective as parenteral Penicillin G without its side effects such as pain and anaphylaxis and could be considered as an alternative treatment in acute odontogenic infection.

Item Type: Article
Subjects: WU Dentistry. Oral surgery
Divisions: Journals > Journal of Mashhad Dental School
Depositing User: jmds jmds
Date Deposited: 23 Sep 2017 15:47
Last Modified: 23 Sep 2017 15:47
URI: http://eprints.mums.ac.ir/id/eprint/2854

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