Effect of curcumin, the active constituent of turmeric, on penicillin-induced epileptiform activity in rats

Tamaddonfard, Esmaeal and Erfanparast, Amir and Hamzeh-Gooshchi, Nasrin and Yousofizadeh, Shahnaz (2012) Effect of curcumin, the active constituent of turmeric, on penicillin-induced epileptiform activity in rats. Avicenna Journal of Phytomedicine, 2 (4). pp. 196-205.

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Abstract

Objective: Curcumin is a major constituent of turmeric and has many biological functions such as anticancer and anti-inflammatory effects. The present study was conducted to investigate the effects of curcumin and diazepam in separate and combined treatments on penicillin-induced seizures in rats. Materials and Methods: In urethane-anesthetized rats, epileptiform activity was induced by intracortical (i.c.) administration of penicillin (200 IU, 1 µl), and frequency and amplitude of spike waves were analyzed using electrocorticographic recordings. Results: Intraperitoneal (i.p.) injections ofcurcumin at doses of 100 and 200 mg/kg, and intracerebroventricular (i.c.v.) injection of diazepam at a dose of 5 µg significantly (p<0.05) reduced both frequency and amplitude of spike waves. Co-administrations of curcumin (50 mg/kg, i.p.) with diazepam (5 µg, i.c.v.) enhanced the antiepileptic effect of diazepam (5 µg, i.c.v.). Conclusion: The results suggested that both curcumin and diazepam suppressed penicillin-induced epileptiform activity. A potentiation effect was observed between curcumin and diazepam in reducing penicillin-induced seizures.

Item Type: Article
Subjects: QT physiology
QU Biochemistry
W General medicine- Health professions
Divisions: Journals > Avicenna J Phytomedicine
Depositing User: ajp ajp
Date Deposited: 23 Sep 2017 17:09
Last Modified: 23 Sep 2017 17:09
URI: http://eprints.mums.ac.ir/id/eprint/2952

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