Evaluation of loading efficiency of azelaic acid-chitosan particles using artificial neural networks

Hanafi, Ali and Kamali, Mehdi and Darvishi, Mohammad Hasan and Amani, Amir (2016) Evaluation of loading efficiency of azelaic acid-chitosan particles using artificial neural networks. Nanomedicine Journal, 3 (3). pp. 169-178.

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Abstract

Objective(s): Chitosan, a biodegradable and cationic polysaccharide with increasing applications in biomedicine, possesses many advantages including mucoadhesivity, biocompatibility, and low-immunogenicity. The aim of this study, was investigating the influence of pH, ratio of azelaic acid/chitosan and molecular weight of chitosan on loading efficiency of azelaic acid in chitosan particles. Materials and Methods: A model was generated using artificial neural networks (ANNs) to study interactions between the inputs and their effects on loading of azelaic acid. Results: From the details of the model, pH showed a reverse effect on the loading efficiency. Also, a certain ratio of drug/chitosan (~ 0.7) provided minimum loading efficiency, while molecular weight of chitosan showed no important effect on loading efficiency.Conclusion: In general, pH and drug/chitosan ratio indicated an effect on loading of the drug. pH was the major factor affecting in determining loading efficiency.

Item Type: Article
Subjects: QT physiology
Divisions: Journals > Nanomedicine Journal
Depositing User: nmj nmj
Date Deposited: 23 Sep 2017 17:32
Last Modified: 23 Sep 2017 17:32
URI: http://eprints.mums.ac.ir/id/eprint/3020

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