Neuro-pharmacological effects of Crinum zeylanicum in mice

Tijani, Adeniyi Yahaya and Salawu, Oluwakanyinsola Adeola and Jaiyeoba, Good-luck and Akponso Anuka, Joseph and Hussaini, Isah Marte (2012) Neuro-pharmacological effects of Crinum zeylanicum in mice. Avicenna Journal of Phytomedicine, 2 (3). pp. 162-168.

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Objectives: The aim of present study was to evaluate some effects of Crinum zeylanicum (C. zeylanicum) on central nervous system. Materials and Methods: C. zeylanicum methanolic bulb extract (250-1000 mg/kg orally), 2 mg chlorpromazine and 4 mg diazepam /kg body weight intraperitoneally respectively were tested in mice using Irwin test, pentobarbitone-induced sleep test, spontaneous motor activity, apomorphine-induced stereotype behaviour, and rota-rod performance. Results: The C. zeylanicum bulb extract significantly and dose-dependently decreased apomorphine-induced hyperactivity in mice (p<0.001). The Irwin test revealed dose-dependent central depressant effect of the extract, shortened (p<0.05-0.01) the onset of sleep and prolonged the duration of sleep. The extract produced significant (p<0.05-0.001) and dose- dependent reduction in spontaneous motor activity and apomorphine-induced stereotype behaviours in mice. The extract had no effect on performance of mice on rotarod. Conclusion: The results suggest that the extract may possess sedative principles with potential neuroleptic properties.

Item Type: Article
Subjects: WL Nervous system
QV pharmacology
Divisions: Journals > Avicenna J Phytomedicine
Depositing User: ajp ajp
Date Deposited: 24 Sep 2017 13:30
Last Modified: 24 Sep 2017 13:30

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