Evaluation of the anti–depressant activity of Myristica fragrans (Nutmeg) in male rats

Moinuddin, Ghulam and Devi, Kshama and Kumar Khajuria, Deepak (2012) Evaluation of the anti–depressant activity of Myristica fragrans (Nutmeg) in male rats. Avicenna Journal of Phytomedicine, 2 (2). pp. 72-78.

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Abstract

Objective: The present study was undertaken to evaluate anti-depressant activity of Myristica fragrans(MS). Materials and Methods: Male Wistar rats were subjected to imipramine and herbal extract ofMS for their antidepressant activity using Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST). Results: Administration of MS and imipramine revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to the control group. However, there was no significant potentiation of PST. Conclusion: Our study demonstrated the potential antidepressant activity of MS.

Item Type: Article
Subjects: W General medicine- Health professions
Divisions: Journals > Avicenna J Phytomedicine
Depositing User: ajp ajp
Date Deposited: 24 Sep 2017 13:47
Last Modified: 24 Sep 2017 13:47
URI: http://eprints.mums.ac.ir/id/eprint/3231

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