Evaluation of the Correlation between CD44, Tumor Prognosis and the 5-Year Survival Rate in Patients with Oral Tongue SCC

Kaboodkhani, Reza and Karimi, Ebrahim and Khorsandi Ashtiani, Mohammad Taghi and Kowkabi, Safoura and Firouzifar, Mohammad Reza and Yazdani, Farzad and Yazdani, Nasrin (2016) Evaluation of the Correlation between CD44, Tumor Prognosis and the 5-Year Survival Rate in Patients with Oral Tongue SCC. Iranian Journal of Otorhinolaryngology, 28 (6). pp. 407-411.

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Abstract

Introduction: 90 of the tumors in the head and neck are squamous-cell carcinomas (HNSCC), which have overall 5- year survival rate between 50 -60. CD44 has been shown to be associated with the prognosis. Materials and Methods: Biopsy specimens of 51 patients with oral tongue SCC were evaluated by Immunohistochemistry (IHC) for the CD44 antibody. Results: There was no significant correlation between CD44 and survival (P=0.77), age (P=0.4), CD44 and lymph node metastasis (P=0.87), sex (P=0.947), smoking (P=0.287) and tumor size (P=0.813). However, there was significant correlation between smoking and survival. Conclusion: There are widespread discrepancies among the findings in the literature regarding the prognosis of CD44 expression in OCSCC. Our study shows that the expression of CD44 is not a marker of aggressive behavior in oral tongue SCC. Consequently, CD44 cannot be considered as handy tool to establish the tumor behavior, prognosis and 5- year survival rate of these tumors.

Item Type: Article
Subjects: WV Otolaryngology
Divisions: Journals > Iranian J Otorhinolaryngology
Depositing User: ijo ijo
Date Deposited: 24 Sep 2017 14:39
Last Modified: 24 Sep 2017 14:39
URI: http://eprints.mums.ac.ir/id/eprint/3390

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