Risks associated with preeclampsia: possible mechanisms

Sahebnasagh, Bentolhoda and Hosseinzadeh-Attar, Mohammad Javad and Sharifi, Amrollah (2017) Risks associated with preeclampsia: possible mechanisms. Reviews in Clinical Medicine, 4 (1). pp. 39-44.

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Findings have shown that low serum 25-hydroxy vitamin D level is a possible risk factor for incidence of preeclampsia during pregnancy. Vitamin D has important effects on multiple biological pathways, including angiogenesis. Some studies have shown that vitamin D deficiency is highly prevalent among women suffering from preeclampsia, influencing immune modulation and vascular function. Evidence has shown that an imbalance of pro-antigenic and anti-angiogenic proteins can be considered as a possible etiological factor in the development of preeclampsia. Besides, there is a series of studies linking the renin–angiotensin aldosterone system (RAAS) with preeclampsia. In this article, we review the current studies evaluating the association between maternal vitamin D status and vascular health, metabolism, placental immune function and the risk of preeclampsia. We provided evidence of the different factor involved in the metabolism of vitamin D and vitamin D receptor (VDR) expression, gene regulations, immune function, and chronic disease when vitamin D is used optimally.

Item Type: Article
Subjects: WP Gynecology
Divisions: Journals > Reviews in Clinical Medicine
Depositing User: RCM RCM
Date Deposited: 24 Sep 2017 15:52
Last Modified: 24 Sep 2017 15:52
URI: http://eprints.mums.ac.ir/id/eprint/3516

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