Assessment of osteoinduction by statins in rat

Hushmand, Behzad and Eslami, Behnam and Amooie, Shohreh (2005) Assessment of osteoinduction by statins in rat. Journal of Mashhad Dental School, 29 (Issue). pp. 287-294.

JMDS_Volume 29_Issue ش�%85ار�%87 3,4_Pages 287-294.pdf

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Introduction: To date, studies about the systemic effects of statins on bone tissue have led to different resuts. The aim of this study was to assess the osteoinductivity by statins when injected intramuscularly or subcutaneously in rats. Materials & Methods: In this experimental study, 68 injections of Simvastatin, Lovastatin, Atorvastatin in polyethyleneglycole with 1mg/ml and polyethyleneglycole 300 were injected either S.C in rat`s backs or I.M into their hand and foot. After 6 weeks, the rats were killed and samples of the injection areas were provided and were studied under a microscope. Results: In two of the samples, few bony areas were seen which were a mixture of lamellar and woven bone. Around these areas’ an osteoblastic rim was visible. In another sample, a chondral area with an active mesanchimal connective tissue which was in a differentiation state to become cartilage, was seen. Conclusion: Finding of this study and the gradual differentiation of muscular tissue to bony stem tissue in around samples, confirms the probable osteoinductivity effect of theses compound. To confirm further we propose that this effect should be investigated on stem cell cultures, in vitro. Key words: Rat, osteoinduction, Simvastatin, Lovastatin, Atorvastatin.

Item Type: Article
Subjects: WU Dentistry. Oral surgery
Divisions: Journals > Journal of Mashhad Dental School
Depositing User: jmds jmds
Date Deposited: 25 Sep 2017 13:30
Last Modified: 25 Sep 2017 13:30

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