The comparative effect of fasting with and without caloric restriction in Rat on oxidative stress parameters

Tyagita, Nurina and Nasihun, Taufiqurrachman and Sumarawati, Titiek (2016) The comparative effect of fasting with and without caloric restriction in Rat on oxidative stress parameters. Journal of Fasting and Health, 4 (3). pp. 102-107.

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Abstract

Introduction: Fasting, like Islamic Ramadan Fasting, has been associated with health benefits. Islamic Ramadan fasting, a form of caloric restriction (CR) or alternate day fasting that. Studies suggest a comparable effect of ADF and caloric restriction. Despite the fact that fasting can be considered as a form of dietary restriction, fasters tend to have difficulty to reduce their food intake during non-fasting period by overeating leading to the excessive calorie intake. To compare the effect of fasting with and without caloric restriction in Sprague Dawley rats. Methods: The rats were assigned to one of three groups: ADF with 70 calorie intake (30 CR), ADF with 100 calorie intake (0 CR), and ADF with 140 calorie intake (excessive calorie intake) and AL (fed ad libitum). All groups were subjected to 6 hour fasting per day (9 a.m. until 3 p.m.) or 15 days. The plasma sample was taken for MDA level assessment. Urinary 8-oxodG levels were determined by using ELISA. Results: ADF with 30 calorie restriction (F70) group had the lowest MDA level. Measurement of 8-oxodG level showed that group F70 had the highest production of 8-oxodG. There was an inverse relationship between MDA level and 8-oxodG level meaning the lower MDA level, the lower 8-oxodG levels were produced. Conclusion: ADF fasting with 30 caloric restriction reduce the MDA level but increase 8-oxodG levels. This study suggest the beneficial effect of fasting requires decrease in overall caloric intake.

Item Type: Article
Subjects: WD Nutrition Disease and metabolic diseases
QU Biochemistry
Divisions: Journals > J Fasting And Health
Depositing User: fasting fasting
Date Deposited: 25 Sep 2017 14:51
Last Modified: 25 Sep 2017 14:51
URI: http://eprints.mums.ac.ir/id/eprint/3914

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