Frequency of Klebsiella Pneumoniae Producing Carbapenemase KPC in Clinical specimens of Mashhad during 2014

roudbari, Fateme and Ghazvini, Kiarash and heydari fork, Somayeh and KouhiNoghondar, Mahdi and Amel Jamedar, Saeed and Youssefi, Masoud (2015) Frequency of Klebsiella Pneumoniae Producing Carbapenemase KPC in Clinical specimens of Mashhad during 2014. medical journal of mashhad university of medical sciences, 58 (6). pp. 322-329.

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Abstract

Introduction: Klebsiella pneumoniae producing B-Lactamase is an important medical concern. Therefore we aimed to investigate broad spectrum lactamase KPC-producing Klebsiella pneumoniae in clinical samples in Mashhad during 2014. Material and method After identification by biochemical methods, antibiotic susceptibility of Klebsiella pneumoniae isolates against 10 different antibiotics was identified using disk diffusion technique. To evaluate the presence of carbapenemase KPC enzyme, modified Hodge test (MHT) was performed and the minimum inhibitory concentration (MIC) of Meropenem as an indicator of Carbapenem class of β-Lactam antibiotics was determined using agar dilution test. Results Among the isolated bacteria, high level of resistance against cefazolin (54.44), cefepime (49.46), ceftazidime (45.19), trimethoprim-sulfamethoxazole (46.26) was observed. Modified Hodge test was performed for all 136 ESBL Klebsiella pneumoniaisolates and 20 were found to be positive for MHT. Furthered MIC test revealed that 2 isolate had MIC=4 μg/ml, 3 isolate had MIC=2, and remaining 15 isolates had MIC more than 8. Conclusion This study underscores the risk of increasing carbapenem resistant Klebsiella pneumonia specieswhich demands further attention in clinical settings.

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 25 Sep 2017 15:53
Last Modified: 25 Sep 2017 15:53
URI: http://eprints.mums.ac.ir/id/eprint/4093

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