Effect of Antibiotic Stewardship targeted against vancomycin and carbapenems on antibiotic use in PICU of Doctor Sheikh hospital

Mohammadi, Farzaneh and Khademi, Gholamreza and Afzalaghaee, Monavar and Sasan, Mohammad Saeed (2015) Effect of Antibiotic Stewardship targeted against vancomycin and carbapenems on antibiotic use in PICU of Doctor Sheikh hospital. medical journal of mashhad university of medical sciences, 58 (5). pp. 263-269.

[img]
Preview
Text
MJMS_Volume 58_Issue 5_Pages 263-269.pdf

Download (684kB) | Preview
Official URL: http://mjms.mums.ac.ir/article_4744.html

Abstract

Introduction: The inappropriate use of Broad- Spectrum antimicrobials in ICUs is a universal problem. The main goal of this study was to implement antibiotic stewardship program (ABS) concentrated on vancomycin and carbapenems, in ICU of Sheikh hospital. As an accessory purpose we also looked for the effect of ABS on the rate of antibiotic (AB) administration, length of hospital stay and mortality Material and Methods: This study was performed in 2 stages, at the first phase; we determined the causes of nosocomial sepsis and their AB resistance pattern in the ICU, and then according to those findings a guideline for administration of vancomycin and carbapenems was performed. In the second stage the files of ICU patients were reviewed every other day (for 3 months), and recommendations about the compatibility of the prescriptions with the guideline were given to the responsible doctor. At the end, we compared the effects of the intervention with one month of prospective record of AB prescriptions without any recommendation. Results: We recorded 1676 and 673 patient/days during 3 month of ABS and 1 month of control. During ABS period, vancomycin use decreased from 294 to 178 for 1000 patient/days (P=0.001), carbapenems administration changed from 433 to 193 for 1000 patient/ days (P=0.001), the LHS decreased from 11.4 to 8.4 days (P=0.06) and mortality rate decreased from 10.2 to 7 (P=0.4).  Conclusion: In a situation like Dr Sheikh ICU , implementation of ABS for vancomycin and carbapenems  hasafavorable effect on AB usage rate.

Item Type: Article
Subjects: WA Public Health
Divisions: Journals > Medical J Mashhad University of Medical Sciences
Depositing User: mjmums mjmums
Date Deposited: 25 Sep 2017 16:04
Last Modified: 25 Sep 2017 16:04
URI: http://eprints.mums.ac.ir/id/eprint/4134

Actions (login required)

View Item View Item