Assessment of the Relationship between Absorbed Skin Dose and Chronic Dermal Side-Effects of Radiotherapy in Patients with Breast Cancer

Homaee Shandiz, Fatemeh and Salek, Raham and Amirabadi, Amir and Moazzen, Nasrin and Fazl Ersi, Mitra (2014) Assessment of the Relationship between Absorbed Skin Dose and Chronic Dermal Side-Effects of Radiotherapy in Patients with Breast Cancer. The Iranian Journal of Obstetrics, Gynecology and Infertility, 17 (116). pp. 1-7.

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Abstract

Introduction: Considering the increasing incidence of breast cancer and patients’ delayed referral to healthcare centers, a large number of these patients are potential candidates for mastectomy and radiotherapy and will eventually suffer from early- or late-onset complications. In this study, we aimed to investigate the prevalence of chronic radiation-induced skin complications and its relation with radiation dose at skin surface in breast radiation of female patients with breast cancer. Methods: Overall, 194 female patients with non-metastatic breast cancer, who had undergone locoregional radiation therapy of breast and regional lymph nodes during 1999-2009, were enrolled in this cross-sectional study. Chronic skin complications induced by breast radiation were assessed, based on the classification of Radiation Therapy Oncology Group (RTOG). For data analysis, Chi-square and Fisher’s exact test were performed, using SPSS version 18. P-value less than 0.05 was considered statistically significant. Results: Among 194 patients evaluated in this study, 55 subjects (28.4) did not have any skin complications (grade 0). On the other hand, 50 (25.8), 42 (21.6), 16 (21.6), and 31 (12.6) patients had grade 1, grade 2, grade 3, and grade 4 complications, based on RTOG system, respectively. Our results showed that radiation dose at skin surface had a significant impact on the incidence of chronic skin complications. Moreover, increase in maximum skin dose was significantly correlated with chronic skin complications (P=0.009). Conclusion: As the results indicated, radiation dose at skin surface during radiotherapy is significantly correlated with chronic skin complications, and this relation should be considered in treatment planning.

Item Type: Article
Subjects: WP Gynecology
WQ Obstetrics
Divisions: Journals > Iranian J Obstetrics, Gynecology and Infertility
Depositing User: ijogi ijogi
Date Deposited: 25 Sep 2017 16:22
Last Modified: 25 Sep 2017 16:22
URI: http://eprints.mums.ac.ir/id/eprint/4187

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