Distribution of Cytomegalovirus Infection in Spontaneous Abortion

Janan, Armaghan and Honarmand, Hamidreza and Amirmozafari, Noor and Asgharnia, Masoumeh and Janan, Arghavan (2014) Distribution of Cytomegalovirus Infection in Spontaneous Abortion. The Iranian Journal of Obstetrics, Gynecology and Infertility, 17 (102). pp. 12-19.

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Introduction: Primary Cytomegalovirus (CMV) infection occurs in 0.15-2 of all pregnancies and transfers to fetus up to 40 that some of these cases lead to abortion. Acute CMV infection in first trimester causes the most severe damage on fetus. The aim of this study wasinvestigation the distribution of cytomegalovirus infection in spontaneous abortion cases by investigating the frequency of primary, reinfection and reactivated CMV infections in mothers. Methods: In this cross sectional study, 40 cases of abortion which were referred to Mehr Fertility Institute of Rasht, Iran during the second 6 month of 2010 were studied for maternal CMV infections (primary, reactivated, and reinfection using ELISA assay to detect antibodies including CMV-IgM ,CMV-IgG and CMV-IgG avidity in sera of mothers. Data were analyzed using Chi-square test. P value less than 0.05 was considered significant. Results: Seroprevalence of positive CMV-IgG in studied women was 100.0 and all of them had high seropositivity rate (≥60RU/ml) as well. About 7 subjects (17.5) had primary infections (CMW-IgM positive with low CMV-IgG avidity). Frequency of primary cytomegalovirus infection in abortions was statistically significant in cases with abortion (p= 0.0001). Conclusion: Results of the present study showed seropositivity to CMV-IgG even with high titer is not a good indicator for mother immunity and can not avoid occurrence of reinfection. Screening with CMV-IgG in pregnancy in not valuable but regarding to high rate frequency of primary infection in abortions, it seems that survey of pregnant women for these infections with measuring CMV-IgM and CMV-IgG avidity is worthy.

Item Type: Article
Subjects: WP Gynecology
WQ Obstetrics
Divisions: Journals > Iranian J Obstetrics, Gynecology and Infertility
Depositing User: ijogi ijogi
Date Deposited: 25 Sep 2017 17:32
Last Modified: 25 Sep 2017 17:32
URI: http://eprints.mums.ac.ir/id/eprint/4331

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