The Analgesic Effects of Gabapentin after Total Abdominal Hysterectomy

Mansour Ghanaee, Mandana and Mirblook, Fariba and Boini, Soheila and Erfani Sayyar, Reza and Shakiba, Maryam and Naghdi Pour, Misa and Rahmani, Shaghayegh (2012) The Analgesic Effects of Gabapentin after Total Abdominal Hysterectomy. The Iranian Journal of Obstetrics, Gynecology and Infertility, 15 (1). pp. 17-25.

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Abstract

Introduction: Postoperative pain is a major problem in general surgery which can severely effect on patient. Studies have shown that gabapantin can produce analgesia and reduce the need for opioids in postoperative patients. In this study the efficacy of gabapantin were studied as a premedication for reduce pain and need for opioids in abdominal hysterectomy. Methods: This double-blind clinical trial was performed in Alzahra maternity of Rasht in 2011. 60 patients who undergo elective abdominal hysterectomy randomly were divided into gabapantin group (1200mg) and placebo group (capsule like gabapantin). Patients visited immediately after recovery and on second and forth hours after surgery in recovery room and VAS was recorded. Data were analyzed with SPSS version 16 by t-student and Mann-Whitney tests. Results: Age and surgery duration were matched in both groups. VAS was significantly difference in two groups for each of 3 visiting times (p=0.0001). Also the need for petidine was significantly more in control group than case group (p=0.0001). Conclusion: Administration of gabapantin can reduce postoperative pain and improve sedation after surgery. Gabapantin as a premedication can also reduce need for opioids prescription.

Item Type: Article
Subjects: WP Gynecology
WQ Obstetrics
Divisions: Journals > Iranian J Obstetrics, Gynecology and Infertility
Depositing User: ijogi ijogi
Date Deposited: 25 Sep 2017 18:31
Last Modified: 25 Sep 2017 18:31
URI: http://eprints.mums.ac.ir/id/eprint/4434

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