Unexplained High Activity of Aspartate Aminotransferase in an Asymptomatic Pediatric Patient

Maan, Wajiha and Warsi, Qurratul Ann and Rashed, Avideh and Karjoo, Manoochehr (2017) Unexplained High Activity of Aspartate Aminotransferase in an Asymptomatic Pediatric Patient. International Journal of Pediatrics, 5 (10). pp. 5805-5808.

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Abstract

Elevated enzyme activities in plasma may at times be attributed to the presence of macro-enzymes. The macro-enzymes are often serum enzymes in complex with immunoglobulins, resulting in a greater molecular mass that cannot be filtered by renal glomeruli and are, hence, retained in the plasma. The aspartate aminotransferase (AST) can exist as a macro-enzyme, although it has been rarely reported. We describe a pediatric patient with persistently elevated serum AST activity, due to macro-enzyme formation between AST and an immunoglobulin. This is to highlight the importance of early diagnosis of macro-AST in an otherwise asymptomatic pediatric patient with isolated AST-elevation and to avoid unnecessary costly testing.

Item Type: Article
Subjects: WS Pediatrics
QU Biochemistry
Divisions: Journals > International J Pediatrics
Depositing User: IJP IJP
Date Deposited: 04 Sep 2017 16:37
Last Modified: 18 Sep 2017 23:01
URI: http://eprints.mums.ac.ir/id/eprint/473

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