Growth factors in cystic fibrosis

Khalighi, Negar and Vakili, Rahim and kiani, Mohammad Ali and Jafari, Seyed Ali and Kianifar, Hamid Reza (2016) Growth factors in cystic fibrosis. Reviews in Clinical Medicine, 3 (1). pp. 13-17.

RCM_Volume 3_Issue 1_Pages 13-17.pdf

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Introduction: Cystic fibrosis is one of the most common autosomal recessive diseases that affects sweat glands and mucosa. CF is a hereditary disease with annual incidence of about 2500 new cases in United Kingdom. Insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 levels decrease in CF. The aim of this study was to assess the role of growth peptides in patients with CF. Method: We searched PubMed, Google scholar, IranMedex, and Scientific Information Database (SID) in September 2012 to April 2014. We included clinical studies with available abstracts and full texts that were in English or Persian languages. Manual searching was conducted within the reference lists of articles. Two reviewers independently applied eligibility criteria, assessed quality, and extracted data.Result: The earliest study was published in 1997 and the most recent one was in 2014. Study participants were adults in 3 studies (20) and 12 studies (80) were conducted in children. Patients with CF have lower levels of IGF-1 and there is a significant correlation between IGF-1 levels and growth index in patients with CF.Conclusions: IGF-1 decreases in children with CF and might be the cause of poor growth and low body mass index in these children.

Item Type: Article
Subjects: WS Pediatrics
Divisions: Journals > Reviews in Clinical Medicine
Depositing User: RCM RCM
Date Deposited: 28 Sep 2017 15:01
Last Modified: 28 Sep 2017 15:01

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