Comparing Ceftriaxone plus Azithromycin or Doxycycline for Outpatient Treatment in Pelvic Inflammatory Disease

Ghomian, Nayereh and Hafizi, Leyli and Tavassoli, Fatemeh and Ahrari roodi, Tahereh (2012) Comparing Ceftriaxone plus Azithromycin or Doxycycline for Outpatient Treatment in Pelvic Inflammatory Disease. The Iranian Journal of Obstetrics, Gynecology and Infertility, 14 (8). pp. 1-8.

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Introduction: Pelvic inflammatory disease is one of the most important complications of upper genital tract infections and common cause of infertility and chronic pelvic pain in women. One of the most common causes of PID is Chlamydia trachomatis. Azithromycin, have important role in treatment of genital Chlamydia infection and use of two doses of this drug is comparable with 14-days of Doxycycline. In this study, we compared the effect of these two drugs. Methods: This clinical trial is carried out on 144 women with mild PID from April 2009 to May 2010 who were referred to Women's clinic of Imam Reza hospital and they are randomly divided into two groups (72 Cases in each group). One group was treated by Doxycycline 100mg/BID/14d and other group treated by oral Azithromycin 1g single dose that was repeated a week later. Both groups received single-dose of Ceftriaxone 250mg/IM. The partners of both groups took Ceftriaxone and Doxycycline. Pain and tenderness were evaluated in the MCPS &amp; VAS system in the first, 7th and 14th day and were collected with personal details (age, parity, method of contraception, history of PID, employment status) in questionnaires. In this survey we used customary methods of descriptive statistic for introduction of research’s data, independent statistical T test and if abnormal, Man Whitney test for quantitative variants and x2 test for qualitative variants to compare two groups and analyze the results. Statistical analyses were done with SPSS version 13. Results: Response to treatment occurred in 66 patients (91.7) of the Azithromycin group and 64 patients (88.9) in the Doxycycline group (p>0.05). Discontinuation of treatment was seen in 12 patients (14.3) in Doxycycline group and no patient (0) in the Azithromycin group (p<0.05). Conclusion: Azithromycin regimen is better than Doxycycline regimen because of same response and only 2 doses instead of 28 doses.

Item Type: Article
Subjects: WP Gynecology
WQ Obstetrics
Divisions: Journals > Iranian J Obstetrics, Gynecology and Infertility
Depositing User: ijogi ijogi
Date Deposited: 26 Sep 2017 18:30
Last Modified: 26 Sep 2017 18:30

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