The role of exosomes contents on genetic and epigenetic alterations of recipient cancer cells

Dehbashi Behbahani, Golnoush and Khani, Soghra and Mahmoodzadeh Hosseini, Hamideh and Abbaszadeh-Goudarzi, Kazem and Nazeri, Saeed (2016) The role of exosomes contents on genetic and epigenetic alterations of recipient cancer cells. Iranian Journal of Basic Medical Sciences, 19 (10). pp. 1031-1039.

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Abstract

Exosomes, as a mediator of cell-to-cell transfer of genetic information, act an important role in intercommunication between tumor cells and their niche including fibroblasts, endothelial cells, adipocytes and monocytes. Several studies have shown that tumor cells can influence their neighboring cells by releasing exosomes. These exosomes provide signaling cues for stimulation, activation, proliferation and differentiation of cells. Exosomes contain mRNAs, microRNAs (miRNA), and proteins that could be transferred to target cells inducing genetic and epigenetic changes. By facilitating the horizontal transfer of bioactive molecules such as proteins, RNAs and microRNAs, they are now thought to have vital roles in tumor invasion and metastases, inflammation, coagulation, and stem cell renewal and expansion. The aim of this review article is to discuss the significance of exosome-mediated intercellular communication within the tumor biology.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 27 Sep 2017 15:57
Last Modified: 27 Sep 2017 15:57
URI: http://eprints.mums.ac.ir/id/eprint/5293

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