Prednison provokes serum and vasoactive substances in a mice model of immune thrombocytopenia

Zhang, Ling and Chen, Ke and Li, Tiantian and He, Hao and Hou, Li and Wu, Xiaoyong and Sun, Yanping and Zheng, Lei and Chen, Zhixiong and Qin, Bei and Chen, Xinyi and Tian, Shaodan (2016) Prednison provokes serum and vasoactive substances in a mice model of immune thrombocytopenia. Iranian Journal of Basic Medical Sciences, 19 (9). pp. 1010-1015.

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Abstract

Objective(s): The main objective of this study was to investigate the variations of β-endorphin (β-EP), vasoactive intestinal peptide (VIP), serotonin (5-HT) and norepinephrine (NE) of immune thrombocytopenia (ITP) mice as well as the regulatory mechanism of prednison. Materials and Methods: Sixty BALB/c mice were randomly divided into control group, model group and prednison intervention group. ITP mice model was duplicated by injecting with glycoprotein-antiplatelet serum (GP-APS) except in control group. After ITP disease model was successful established, prednison was used in prednison intervention group. The β-EP, VIP, 5-HT and NE contents of ITP mice were detected by enzyme linked immunosorbent assay (ELISA). Results:Compared with the values in control group, the detection values of VIP and 5-HT in model group declined, while the detection values of β-EP and NE increased. Compared with prednison intervention group, the detection values of VIP and 5-HT in model group increased, while the detection values of β-EP and NE showed no significant change. Conclusion: In this study, the β-EP, VIP, 5-HT and NE contents in ITP mice injected with GP-APS were changed by prednison. It shows that prednison as the first-line therapy for ITP with effective hemostasis function is likely to increasing the contents of VIP and 5-HT. These results suggest the therapeutic value of prednison for the treatment of ITP.

Item Type: Article
Subjects: QV pharmacology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 27 Sep 2017 16:41
Last Modified: 27 Sep 2017 16:41
URI: http://eprints.mums.ac.ir/id/eprint/5558

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