The effects of unilateral varicose ovarian vein on antioxidant capacity and oocyte quality in rat ovary

Adebayo Kehinde, Babatunde and Abolhassani, Farid and Yazdekhasti, Hossein and Abbasi, Niloufar and Heydari, Leyla and Daneshi, Erfan and Rajabi, Zahra and Hamada, Alaa and Agarwal, Ashok and Abbasi, Mehdi (2016) The effects of unilateral varicose ovarian vein on antioxidant capacity and oocyte quality in rat ovary. Iranian Journal of Basic Medical Sciences, 19 (8). pp. 863-869.

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Abstract

Objective(s): Several researchers have reported the relationship between infertility in male and varicocele for so many years but the implication of varicocele in female patients is remains elusive. Here, we aim to examine the effects of unilateral varicose ovarian vein on antioxidant capacity and oocyte quality of rat ovary after the experimental creation of varicocele in female rats. Materials and Methods: In this study, thirty adult female albino rats were divided into three equal groups: Group 1 as the control group has 10 rats, Group 2 as the sham group has 10 rats and they underwent a sham operation and finally Group 3 has the varicocele group has 10 rats. Antioxidant assays for superoxide dismutase, glutathioneperoxidase and catalase were performed using specific assay kits and gene expression for Bax, Bmp-15, Hsp-27 and Gdf-9 was done via real time PCR. Results: The adverse effects of the experimentally induced varicocele were reported and recorded on the left ovary compared to the right sided ovary (no varicocele induction) in the varicocele group. Real time PCR data shows that the expression of Gdf-9, Hsp-27 and Bmp-15 genes were all significantly reduced at P≤0.05. Conclusion: The results of this study show that reduced gene expression of Bmp-15, Gdf-9 and Hsp-27, increased gene expression of bax and an imbalance between pro-oxidant/ antioxidant ratio are few of the several mechanisms by which varicocele may lead to infertility in female.

Item Type: Article
Subjects: QT physiology
Divisions: Journals > Iranian J Basic Medical Sciences
Depositing User: ijbms ijbms
Date Deposited: 27 Sep 2017 17:32
Last Modified: 27 Sep 2017 17:32
URI: http://eprints.mums.ac.ir/id/eprint/5661

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