Soluble Mediators in Posttraumatic Wrist and Primary Knee Osteoarthritis

Teunis, Teun and Beekhuizen, Michiel and Van Osch, Gerjo V.M. and Schuurman, Arnold H. and Creemers, Laura B. and van Minnen, L. Paul (2014) Soluble Mediators in Posttraumatic Wrist and Primary Knee Osteoarthritis. The Archives of Bone and Joint Surgery, 2 (3). pp. 146-150.

[img]
Preview
Text
ABJS_Volume 2_Issue 3_Pages 146-150.pdf

Download (368kB) | Preview
Official URL: http://abjs.mums.ac.ir/article_3355.html

Abstract

Background: New discoveries about the pathophysiology changed the concept that all forms of osteoarthritis are alike; this lead to the delineation of different phenotypes such as age, trauma or obese related forms. We aim to compare soluble mediator profiles in primary knee and posttraumatic wrist osteoarthritis. Based on the general faster progression rate of wrist osteoarthritis, we hypothesize a more inflammatory profile. Methods: We collected synovial fluid from 20 primary osteoarthritic knee and 20 posttraumatic osteoarthritic wrist joints. 17 mediators were measured by multiplex enzyme-linked immunosorbent assay: chemokine ligand 5, interferon-γ, leukemia inhibitory factor, oncostatin-M, osteoprotegerin, tumor necrosis factor-α, vascular endothelial growth factor, interleukin (IL)-1α, IL-1β, IL-1 receptor antagonist, IL-4, IL-6, IL-7, IL-8, IL-10, IL-13 and IL-17. Results: Ten mediators were higher in posttraumatic osteoarthritic synovial fluid: tumor necrosis factor-α (TNFα), IL-1α, IL-1RA, IL-6, IL-10, IL-17, oncostatin-M, interferon-γ, chemokine ligand 5 and leukemia inhibitory factor(P<0.001). IL-1ß, IL-4, IL-7 were not detected, TNFα was not detected in knee osteoarthritic synovial fluid. IL-8, IL-13, osteoprotegerin and vascular endothelial growth factor levels did not differ between the synovial fluid types. Conclusions: In general wrist osteoarthritis seems characterized by a stronger inflammatory response than primary knee osteoarthritis. More pronounced inflammatory mediators might offer a paradigm for the faster progression of posttraumatic osteoarthritis. Increase of specific mediators could form a possible target for future mediator modulating therapy in wrist osteoarthritis.

Item Type: Article
Subjects: WE Musculoskeletal system
WO Surgery
Divisions: Journals > Archives of Bone & Joint Surgery
Depositing User: abjs abjs
Date Deposited: 28 Sep 2017 14:47
Last Modified: 28 Sep 2017 14:47
URI: http://eprints.mums.ac.ir/id/eprint/5690

Actions (login required)

View Item View Item