Comparison of Effects of Hyoscine N-Butyl Bromide and Promethazine on Length of Active Phase of First Stage of Labor

Ebrahimzadeh Zagami, Samira and Golmakani, Nahid and Saadatjoo, Seyyed Ali-Reza and Dadgar, Salameh and Baghbani, Behjat (2012) Comparison of Effects of Hyoscine N-Butyl Bromide and Promethazine on Length of Active Phase of First Stage of Labor. The Iranian Journal of Obstetrics, Gynecology and Infertility, 15 (6). pp. 16-21.

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Abstract

Introduction: Shortening duration of delivery without endangering mother and fetus is always highly considered by obstetric specialist and mothers. Widely use of Hyoscine N-butyl bromide and Promethazine in hospitals and limited researches with conflicting results in this regard made us investigate the efficiency of Hyoscine N-butyl bromide and Promethazine on length of active phase of the first stage of labor. Methods: A provident double-blind clinical trial was done on 188 nulliparous women. They were classified into the Hyoscine N-butyl bromide (48cases), Promethazine (45cases) and control (95 cases) groups. The samples were randomly allocated from cases who were injected 20 mg of Hyoscine N-butyl bromide, 25 mg of Promethazine IM in dilatation 3-5cm, and control group in which no medicine was used. Data analysis was performed using SPSS software version 16, t- test, chi-square and ANOVA tests. p<0.05 was considered significant. Results: The mean duration of active phase of labor in Promethazine (5.69±3.45) was shorter than in control group (7±3.44). This difference was statistically significant (p=0.049). However duration of active phase of labor had no statistically significant difference between Hyoscine N-butyl bromide and control groups (p=0.205). However, the mean duration of active phase of labor was not statistically significant in the three groups of Hyoscine N-butyl bromide, Promethazine and control (p=0.140). Conclusion: It seems that Promethazine can be used as an effective drug to shorten the length of laboring in comparison with Hyoscine N-butyl bromide.

Item Type: Article
Subjects: WP Gynecology
WQ Obstetrics
Divisions: Journals > Iranian J Obstetrics, Gynecology and Infertility
Depositing User: ijogi ijogi
Date Deposited: 27 Sep 2017 18:02
Last Modified: 27 Sep 2017 18:02
URI: http://eprints.mums.ac.ir/id/eprint/5769

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